Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912242323> ?p ?o ?g. }
- W2912242323 abstract "ABSTRACT In embryos, lineage-specific profiles of chromatin accessibility control gene expression by modulating transcription, and thus impact multipotent progenitor states and subsequent fate choices. Subsets of cardiac and pharyngeal/head muscles share a common origin in the cardiopharyngeal mesoderm, but the chromatin landscapes that govern multipotent progenitors’ competence and early fate choices remain largely elusive. Here, we leveraged the simplicity of the chordate model Ciona to profile chromatin accessibility through stereotyped transitions from naive Mesp + mesoderm to distinct fate-restricted heart and pharyngeal muscle precursors. An FGF-Foxf pathway acts in multipotent progenitors to establish cardiopharyngeal-specific patterns of accessibility, which govern later heart vs. pharyngeal muscle-specific expression profiles, demonstrating extensive spatiotemporal decoupling between early cardiopharyngeal enhancer accessibility and late cell-type-specific activity. Combinations of cis -regulatory elements with distinct chromatin accessibility profiles are required to activate of Ebf and Tbx1/10 , two key determinants of cardiopharyngeal fate choices. We propose that this higher order combinatorial logic increases the repertoire of regulatory inputs that control gene expression, through either accessibility and/or activity, thus fostering spatially and temporally accurate fate choices." @default.
- W2912242323 created "2019-02-21" @default.
- W2912242323 creator A5009364314 @default.
- W2912242323 creator A5061301740 @default.
- W2912242323 creator A5080705309 @default.
- W2912242323 date "2019-02-11" @default.
- W2912242323 modified "2023-09-23" @default.
- W2912242323 title "Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices" @default.
- W2912242323 cites W1964430638 @default.
- W2912242323 cites W1968975770 @default.
- W2912242323 cites W1971578941 @default.
- W2912242323 cites W1978125302 @default.
- W2912242323 cites W1987377638 @default.
- W2912242323 cites W1989063274 @default.
- W2912242323 cites W1997271589 @default.
- W2912242323 cites W2005144583 @default.
- W2912242323 cites W2006028524 @default.
- W2912242323 cites W2007542500 @default.
- W2912242323 cites W2011535817 @default.
- W2912242323 cites W2014677321 @default.
- W2912242323 cites W2015816004 @default.
- W2912242323 cites W2016597274 @default.
- W2912242323 cites W2017692217 @default.
- W2912242323 cites W2022265743 @default.
- W2912242323 cites W2025559562 @default.
- W2912242323 cites W2026960397 @default.
- W2912242323 cites W2029172483 @default.
- W2912242323 cites W2036614198 @default.
- W2912242323 cites W2039039878 @default.
- W2912242323 cites W2043270554 @default.
- W2912242323 cites W2060309330 @default.
- W2912242323 cites W2061641782 @default.
- W2912242323 cites W2063853502 @default.
- W2912242323 cites W2064586774 @default.
- W2912242323 cites W2072230411 @default.
- W2912242323 cites W2073097315 @default.
- W2912242323 cites W2075928340 @default.
- W2912242323 cites W2077327685 @default.
- W2912242323 cites W2080494915 @default.
- W2912242323 cites W2082793267 @default.
- W2912242323 cites W2082833696 @default.
- W2912242323 cites W2084880861 @default.
- W2912242323 cites W2091732296 @default.
- W2912242323 cites W2092081087 @default.
- W2912242323 cites W2094577119 @default.
- W2912242323 cites W2104276565 @default.
- W2912242323 cites W2104829093 @default.
- W2912242323 cites W2106448802 @default.
- W2912242323 cites W2111128689 @default.
- W2912242323 cites W2112395856 @default.
- W2912242323 cites W2115798328 @default.
- W2912242323 cites W2117757143 @default.
- W2912242323 cites W2122097157 @default.
- W2912242323 cites W2125427437 @default.
- W2912242323 cites W2128151873 @default.
- W2912242323 cites W2136377722 @default.
- W2912242323 cites W2142544428 @default.
- W2912242323 cites W2146927398 @default.
- W2912242323 cites W2147769296 @default.
- W2912242323 cites W2151484485 @default.
- W2912242323 cites W2155987935 @default.
- W2912242323 cites W2160357139 @default.
- W2912242323 cites W2171808845 @default.
- W2912242323 cites W2179438025 @default.
- W2912242323 cites W2223204119 @default.
- W2912242323 cites W2341367979 @default.
- W2912242323 cites W2511963020 @default.
- W2912242323 cites W2556513628 @default.
- W2912242323 cites W2625667994 @default.
- W2912242323 cites W2651497858 @default.
- W2912242323 cites W2736547131 @default.
- W2912242323 cites W2750049634 @default.
- W2912242323 cites W2765828394 @default.
- W2912242323 cites W2770344858 @default.
- W2912242323 cites W2783335334 @default.
- W2912242323 cites W2784600881 @default.
- W2912242323 cites W2786200396 @default.
- W2912242323 cites W2790027875 @default.
- W2912242323 cites W2798436105 @default.
- W2912242323 cites W2883299919 @default.
- W2912242323 cites W2901453315 @default.
- W2912242323 cites W2911555896 @default.
- W2912242323 cites W2950599556 @default.
- W2912242323 cites W2951019515 @default.
- W2912242323 cites W3104778719 @default.
- W2912242323 doi "https://doi.org/10.1101/546945" @default.
- W2912242323 hasPublicationYear "2019" @default.
- W2912242323 type Work @default.
- W2912242323 sameAs 2912242323 @default.
- W2912242323 citedByCount "6" @default.
- W2912242323 countsByYear W29122423232018 @default.
- W2912242323 countsByYear W29122423232019 @default.
- W2912242323 countsByYear W29122423232020 @default.
- W2912242323 crossrefType "posted-content" @default.
- W2912242323 hasAuthorship W2912242323A5009364314 @default.
- W2912242323 hasAuthorship W2912242323A5061301740 @default.
- W2912242323 hasAuthorship W2912242323A5080705309 @default.
- W2912242323 hasBestOaLocation W29122423231 @default.
- W2912242323 hasConcept C104317684 @default.
- W2912242323 hasConcept C111936080 @default.