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• W2912242718 endingPage "34" @default.
• W2912242718 startingPage "24" @default.
• W2912242718 abstract "Auditory-nerve fibers are lost steadily with age and as a possible consequence of noise-induced glutamate excitotoxicity. Auditory-nerve loss in the absence of other cochlear pathologies is thought to be undetectable with a pure-tone audiogram while degrading real-world speech perception (hidden hearing loss). Perceptual deficits remain unclear, however, due in part to the limited behavioral capacity of existing rodent models to discriminate complex sounds. The budgerigar is an avian vocal learner with human-like behavioral sensitivity to many simple and complex sounds and the capacity to mimic speech. Previous studies in this species show that intracochlear kainic-acid infusion reduces wave 1 of the auditory brainstem response by 40–70%, consistent with substantial excitotoxic auditory-nerve damage. The present study used operant-conditioning procedures in trained budgerigars to quantify kainic-acid effects on tone detection across frequency (0.25–8 kHz; the audiogram) and as a function of duration (20–160 ms; temporal integration). Tone thresholds in control animals were lowest from 1 to 4 kHz and decreased with increasing duration as in previous studies of the budgerigar. Behavioral results in kainic-acid-exposed animals were as sensitive as in controls, suggesting preservation of the audiogram and temporal integration despite auditory-nerve loss associated with up to 70% wave 1 reduction. Distortion-product otoacoustic emissions were also preserved in kainic-acid exposed animals, consistent with normal hair-cell function. These results highlight considerable perceptual resistance of tone-detection performance with selective auditory-nerve loss. Future behavioral studies in budgerigars with auditory-nerve damage can use complex speech-like stimuli to help clarify aspects of auditory perception impacted by this common cochlear pathology." @default.
• W2912242718 created "2019-02-21" @default.
• W2912242718 creator A5049399145 @default.
• W2912242718 creator A5067907644 @default.
• W2912242718 creator A5077072124 @default.
• W2912242718 creator A5078729826 @default.
• W2912242718 creator A5078816065 @default.
• W2912242718 date "2019-03-01" @default.
• W2912242718 modified "2023-10-12" @default.
• W2912242718 title "Effects of selective auditory-nerve damage on the behavioral audiogram and temporal integration in the budgerigar" @default.
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