FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912245883> ?p ?o ?g. }

• W2912245883 abstract "Background: Brain concentrations of omega-3 docosahexaenoic acid (DHA, 22:6n-3) have been reported to positively correlate with seizure thresholds in rodent seizure models. It is not known whether brain DHA depletion, achieved by chronic dietary omega-3 polyunsaturated fatty acid (PUFA) deficiency, lowers seizure thresholds in rats. Objective: The present study tested the hypothesis that lowering brain DHA concentration with chronic dietary n-3 PUFA deprivation in rats will reduce seizure thresholds, and that compared to injected oleic acid (OA), injected DHA will raise seizure thresholds in rats maintained on n-3 PUFA adequate and deficient diets. Methods: Rats (60 days old) were surgically implanted with electrodes in the amygdala, and subsequently randomized to the AIN-93G diet containing adequate levels of n-3 PUFA derived from soybean oil or an n-3 PUFA-deficient diet derived from coconut and safflower oil. The rats were maintained on the diets for 37 weeks. Afterdischarge seizure thresholds (ADTs) were measured every 4-6 weeks by electrically stimulating the amygdala. Between weeks 35 and 37, ADTs were assessed within 1 h of subcutaneous OA or DHA injection (600 mg/kg). Seizure thresholds were also measured in a parallel group of non-implanted rats subjected to the maximal pentylenetetrazol (PTZ, 110 mg/kg) seizure test. PUFA composition was measured in the pyriform-amygdala complex of another group of non-implanted rats sacrificed at 16 and 32 weeks. Results: Dietary n-3 PUFA deprivation did not significantly alter amygdaloid seizure thresholds or latency to PTZ-induced seizures. Acute injection of OA did not alter amygdaloid ADTs of rats on the n-3 PUFA adequate or deficient diets, whereas acute injection of DHA significantly increased amygdaloid ADTs in rats on the n-3 PUFA adequate control diet as compared to rats on the n-3 PUFA deficient diet (P < 0.05). Pyriform-amygdala DHA percent composition did not significantly differ between the groups, while n-6 docosapentaenoic acid, a marker of n-3 PUFA deficiency, was significantly increased by 2.9-fold at 32 weeks. Conclusion: Chronic dietary n-3 PUFA deficiency does not alter seizure thresholds in rats, but may prevent the anti-seizure effects of DHA." @default.
• W2912245883 created "2019-02-21" @default.
• W2912245883 creator A5007008229 @default.
• W2912245883 creator A5021564789 @default.
• W2912245883 creator A5025245627 @default.
• W2912245883 creator A5027965558 @default.
• W2912245883 creator A5030051787 @default.
• W2912245883 creator A5035387052 @default.
• W2912245883 creator A5035894652 @default.
• W2912245883 creator A5069833653 @default.
• W2912245883 date "2019-02-05" @default.
• W2912245883 modified "2023-09-26" @default.
• W2912245883 title "Dietary Omega-3 Polyunsaturated Fatty Acid Deprivation Does Not Alter Seizure Thresholds but May Prevent the Anti-seizure Effects of Injected Docosahexaenoic Acid in Rats" @default.
• W2912245883 cites W1489937832 @default.
• W2912245883 cites W1577144537 @default.
• W2912245883 cites W1787497562 @default.
• W2912245883 cites W1960145271 @default.
• W2912245883 cites W1964554927 @default.
• W2912245883 cites W1964721333 @default.
• W2912245883 cites W1964809668 @default.
• W2912245883 cites W1964968173 @default.
• W2912245883 cites W1973611043 @default.
• W2912245883 cites W1977675167 @default.
• W2912245883 cites W1978282844 @default.
• W2912245883 cites W1994570523 @default.
• W2912245883 cites W1996620556 @default.
• W2912245883 cites W2002131557 @default.
• W2912245883 cites W2008830533 @default.
• W2912245883 cites W2013798382 @default.
• W2912245883 cites W2015845858 @default.
• W2912245883 cites W2016002102 @default.
• W2912245883 cites W2016108794 @default.
• W2912245883 cites W2017431732 @default.
• W2912245883 cites W2018432797 @default.
• W2912245883 cites W2024102173 @default.
• W2912245883 cites W2033206035 @default.
• W2912245883 cites W2035264026 @default.
• W2912245883 cites W2049617752 @default.
• W2912245883 cites W2051398228 @default.
• W2912245883 cites W2051798963 @default.
• W2912245883 cites W2053715516 @default.
• W2912245883 cites W2055031312 @default.
• W2912245883 cites W2060750825 @default.
• W2912245883 cites W2064066603 @default.
• W2912245883 cites W2064473675 @default.
• W2912245883 cites W2064609029 @default.
• W2912245883 cites W2084249153 @default.
• W2912245883 cites W2084711222 @default.
• W2912245883 cites W2085065512 @default.
• W2912245883 cites W2094792436 @default.
• W2912245883 cites W2095181763 @default.
• W2912245883 cites W2106387488 @default.
• W2912245883 cites W2110667792 @default.
• W2912245883 cites W2112364257 @default.
• W2912245883 cites W2112573210 @default.
• W2912245883 cites W2114205997 @default.
• W2912245883 cites W2114628261 @default.
• W2912245883 cites W2119775921 @default.
• W2912245883 cites W2126403835 @default.
• W2912245883 cites W2131737404 @default.
• W2912245883 cites W2132614749 @default.
• W2912245883 cites W2161709076 @default.
• W2912245883 cites W2167845835 @default.
• W2912245883 cites W2168526937 @default.
• W2912245883 cites W2181591541 @default.
• W2912245883 cites W2218888203 @default.
• W2912245883 cites W2330756258 @default.
• W2912245883 cites W2336145176 @default.
• W2912245883 cites W2517224823 @default.
• W2912245883 cites W2610929100 @default.
• W2912245883 doi "https://doi.org/10.3389/fneur.2018.01188" @default.
• W2912245883 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6370649" @default.
• W2912245883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30804888" @default.
• W2912245883 hasPublicationYear "2019" @default.
• W2912245883 type Work @default.
• W2912245883 sameAs 2912245883 @default.
• W2912245883 citedByCount "2" @default.
• W2912245883 countsByYear W29122458832021 @default.
• W2912245883 countsByYear W29122458832023 @default.
• W2912245883 crossrefType "journal-article" @default.
• W2912245883 hasAuthorship W2912245883A5007008229 @default.
• W2912245883 hasAuthorship W2912245883A5021564789 @default.
• W2912245883 hasAuthorship W2912245883A5025245627 @default.
• W2912245883 hasAuthorship W2912245883A5027965558 @default.
• W2912245883 hasAuthorship W2912245883A5030051787 @default.
• W2912245883 hasAuthorship W2912245883A5035387052 @default.
• W2912245883 hasAuthorship W2912245883A5035894652 @default.
• W2912245883 hasAuthorship W2912245883A5069833653 @default.
• W2912245883 hasBestOaLocation W29122458831 @default.
• W2912245883 hasConcept C118552586 @default.
• W2912245883 hasConcept C126322002 @default.
• W2912245883 hasConcept C134018914 @default.
• W2912245883 hasConcept C185592680 @default.
• W2912245883 hasConcept C19038510 @default.
• W2912245883 hasConcept C2775858608 @default.
• W2912245883 hasConcept C2776091944 @default.
• W2912245883 hasConcept C2776819090 @default.
• W2912245883 hasConcept C2777010014 @default.
• W2912245883 hasConcept C2777171753 @default.
• W2912245883 hasConcept C2778186239 @default.

• next