FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912247112> ?p ?o ?g. }

• W2912247112 endingPage "339" @default.
• W2912247112 startingPage "304" @default.
• W2912247112 abstract "Gene expression occurs in two essential steps: transcription and translation. In bacteria, the two processes are tightly coupled in time and space, and highly regulated. Tight regulation of gene expression is crucial. It limits wasteful consumption of resources and energy, prevents accumulation of potentially growth inhibiting reaction intermediates, and sustains the fitness and potential virulence of the organism in a fluctuating, competitive and frequently stressful environment. Since the onset of studies on regulation of enzyme synthesis, numerous distinct regulatory mechanisms modulating transcription and/or translation have been discovered. Mostly, various regulatory mechanisms operating at different levels in the flow of genetic information are used in combination to control and modulate the expression of a single gene or operon. Here, we provide an extensive overview of the very diverse and versatile bacterial gene regulatory mechanisms with major emphasis on their combined occurrence, intricate intertwinement and versatility. Furthermore, we discuss the potential of well-characterized basal expression and regulatory elements in synthetic biology applications, where they may ensure orthogonal, predictable and tunable expression of (heterologous) target genes and pathways, aiming at a minimal burden for the host." @default.
• W2912247112 created "2019-02-21" @default.
• W2912247112 creator A5072298237 @default.
• W2912247112 creator A5079443587 @default.
• W2912247112 date "2019-02-04" @default.
• W2912247112 modified "2023-10-02" @default.
• W2912247112 title "Diversity, versatility and complexity of bacterial gene regulation mechanisms: opportunities and drawbacks for applications in synthetic biology" @default.
• W2912247112 cites W1494162265 @default.
• W2912247112 cites W1497378428 @default.
• W2912247112 cites W1502916179 @default.
• W2912247112 cites W1508069518 @default.
• W2912247112 cites W1508202631 @default.
• W2912247112 cites W1531576924 @default.
• W2912247112 cites W1543120839 @default.
• W2912247112 cites W1544147690 @default.
• W2912247112 cites W1552284012 @default.
• W2912247112 cites W1560298788 @default.
• W2912247112 cites W1567938518 @default.
• W2912247112 cites W1569006374 @default.
• W2912247112 cites W1600300375 @default.
• W2912247112 cites W1602765812 @default.
• W2912247112 cites W1658756073 @default.
• W2912247112 cites W1665603416 @default.
• W2912247112 cites W1668599603 @default.
• W2912247112 cites W170456303 @default.
• W2912247112 cites W180545548 @default.
• W2912247112 cites W1812934256 @default.
• W2912247112 cites W1834065866 @default.
• W2912247112 cites W1838917369 @default.
• W2912247112 cites W1917978909 @default.
• W2912247112 cites W1934866768 @default.
• W2912247112 cites W1935374737 @default.
• W2912247112 cites W1936644402 @default.
• W2912247112 cites W1939086318 @default.
• W2912247112 cites W1940073477 @default.
• W2912247112 cites W1941962498 @default.
• W2912247112 cites W1946157893 @default.
• W2912247112 cites W1953084952 @default.
• W2912247112 cites W1957843310 @default.
• W2912247112 cites W1963724731 @default.
• W2912247112 cites W1964126349 @default.
• W2912247112 cites W1964831606 @default.
• W2912247112 cites W1965233744 @default.
• W2912247112 cites W1966192701 @default.
• W2912247112 cites W1966197680 @default.
• W2912247112 cites W1967940571 @default.
• W2912247112 cites W1968366930 @default.
• W2912247112 cites W1968830816 @default.
• W2912247112 cites W1970103400 @default.
• W2912247112 cites W1970258574 @default.
• W2912247112 cites W1970715125 @default.
• W2912247112 cites W1970951396 @default.
• W2912247112 cites W1971298388 @default.
• W2912247112 cites W1972168116 @default.
• W2912247112 cites W1972587297 @default.
• W2912247112 cites W1972803499 @default.
• W2912247112 cites W1973256834 @default.
• W2912247112 cites W1975993241 @default.
• W2912247112 cites W1977280681 @default.
• W2912247112 cites W1977685098 @default.
• W2912247112 cites W1978084083 @default.
• W2912247112 cites W1980265680 @default.
• W2912247112 cites W1980312009 @default.
• W2912247112 cites W1981379092 @default.
• W2912247112 cites W1981577753 @default.
• W2912247112 cites W1982658095 @default.
• W2912247112 cites W1985039493 @default.
• W2912247112 cites W1986842298 @default.
• W2912247112 cites W1987477559 @default.
• W2912247112 cites W1988067659 @default.
• W2912247112 cites W1988517965 @default.
• W2912247112 cites W1989075680 @default.
• W2912247112 cites W1990971756 @default.
• W2912247112 cites W1991453743 @default.
• W2912247112 cites W1991640026 @default.
• W2912247112 cites W1992204008 @default.
• W2912247112 cites W1992223935 @default.
• W2912247112 cites W1992279412 @default.
• W2912247112 cites W1993006141 @default.
• W2912247112 cites W1993154270 @default.
• W2912247112 cites W1994234835 @default.
• W2912247112 cites W1994715746 @default.
• W2912247112 cites W1996577630 @default.
• W2912247112 cites W1996901969 @default.
• W2912247112 cites W1998614048 @default.
• W2912247112 cites W1999325571 @default.
• W2912247112 cites W1999490246 @default.
• W2912247112 cites W1999570631 @default.
• W2912247112 cites W2000213161 @default.
• W2912247112 cites W2000822281 @default.
• W2912247112 cites W2000958357 @default.
• W2912247112 cites W2001055805 @default.
• W2912247112 cites W2001164252 @default.
• W2912247112 cites W2001426985 @default.
• W2912247112 cites W2002645780 @default.
• W2912247112 cites W2003026778 @default.
• W2912247112 cites W2003660859 @default.
• W2912247112 cites W2003912083 @default.

• next