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• W2912249479 abstract "Event Abstract Back to Event Focus on motor inhibition as an actor of action selection Caroline Quoilin1*, Fanny Fievez1 and Julie Duque1 1 Université catholique de Louvain, Institute of Neuroscience, Belgium By applying transcranial magnetic stimulation (TMS) over the primary motor cortex (M1) to elicit motor evoked potentials (MEPs) in muscles of the contralateral hand, many studies have shown that action preparation is associated with a transient decrease in the excitability of the corticospinal pathway. So far, such inhibition has been mainly evaluated during instructed-delay choice reaction time (RT) tasks where the correct response (e.g. a left or right index finger response) is indicated by a preparatory cue, but participants are required to withhold their movement until the onset of a go signal. When TMS is applied during this delay period, MEPs are suppressed regardless of whether they are probed in a muscle that is selected or non-selected for the forthcoming response. Furthermore, a MEP suppression has also been reported when the muscle is task-irrelevant, suggesting the operation of an inhibitory process broadly suppressing motor activity. Several hypotheses have been proposed regarding the functional role of this motor inhibition, including the idea that it may serve to assist action selection. Yet, motor inhibition may also help regulate movement initiation, preventing responses from being released prematurely. The goal of the present study was to investigate the contribution of motor inhibition to action selection. To do so, we used a standard (no-delay) RT task in which the cue also served as the go signal, thus eliminating a potential inhibition related to initiation regulation. TMS was applied at several time points after the go signal in different block types. In the “choice blocks”, subjects had to choose between left and right index finger responses, while they had to always respond either with the left or right index finger in the “simple blocks”. MEPs were elicited in relevant (index agonist) and irrelevant (pinky agonist) muscles using a Double-Coil TMS procedure allowing to obtain nearly-simultaneous MEPs from both hands in each trial. The amplitude of MEPs elicited in the selected index finger progressively increased during action preparation, reflecting the recruitment of the corresponding M1 for the forthcoming movement. Surprisingly, MEPs elicited in the homonymous muscle (index agonist) of the resting hand did not show much change during action preparation, regardless of whether this muscle was part of the initial response set (choice blocks) or not (simple blocks). In fact, motor inhibition was only observed in MEPs elicited in non-homonymous irrelevant muscles (pinky agonist), and this effect was comparable in choice and simple blocks. Altogether, these results indicate that preparatory inhibition is tenuous when probed in standard RT tasks, possibly because concurrent excitatory processes tend to increase MEPs in this context. In addition, our findings did not reveal any impact of choice on MEP suppression, questioning the view that inhibition may serve to assist action selection. Keywords: action selection, Transcranial Magnetic Stimulation, motor inhibition, action preparation, motor evoked potential (MEP) Conference: 12th National Congress of the Belgian Society for Neuroscience, Gent, Belgium, 22 May - 22 May, 2017. Presentation Type: Poster Presentation Topic: Sensory and Motor Systems Citation: Quoilin C, Fievez F and Duque J (2019). Focus on motor inhibition as an actor of action selection. Front. Neurosci. Conference Abstract: 12th National Congress of the Belgian Society for Neuroscience. doi: 10.3389/conf.fnins.2017.94.00116 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 Mar 2017; Published Online: 25 Jan 2019. * Correspondence: PhD. Caroline Quoilin, Université catholique de Louvain, Institute of Neuroscience, Brussels, Belgium, caroline.quoilin@uclouvain.be Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Caroline Quoilin Fanny Fievez Julie Duque Google Caroline Quoilin Fanny Fievez Julie Duque Google Scholar Caroline Quoilin Fanny Fievez Julie Duque PubMed Caroline Quoilin Fanny Fievez Julie Duque Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2912249479 title "Focus on motor inhibition as an actor of action selection" @default.
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