FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912250685> ?p ?o ?g. }

• W2912250685 endingPage "115" @default.
• W2912250685 startingPage "105" @default.
• W2912250685 abstract "MYC transcription factor has critical roles in cell growth, proliferation, metabolism, differentiation, transformation and angiogenesis. MYC overexpression is seen in about 15% of breast cancers and linked to aggressive phenotypes. MYC overexpression also induces oxidative stress and replication stress in cells. ATM signalling and ATR-mediated signalling are critical for MYC-induced DNA damage response. Whether ATM and ATR expressions influence clinical outcomes in MYC overexpressed breast cancers is unknown. We investigated ATM, ATR and MYC at the transcriptional level [Molecular Taxonomy of Breast Cancer International Consortium cohort (n = 1950)] and at the protein level in the Nottingham series comprising 1650 breast tumours. We correlated ATM, ATR and MYC expressions to clinicopathological features and survival outcomes. In MYC over expressed tumours, high ATR or low ATM levels were associated with aggressive breast cancer features such as higher tumour grade, de-differentiation, pleomorphism, high mitotic index, high-risk Nottingham Prognostic Index, triple negative and basal-like breast cancers (all adjusted p values < 0.05). Tumours with low ATM or high ATR levels in conjunction with MYC overexpression also have worse overall breast cancer-specific survival (BCSS) (p value < 0.05). We conclude that ATR/ATM-directed stratification and personalisation of therapy may be feasible in MYC overexpressed breast cancer." @default.
• W2912250685 created "2019-02-21" @default.
• W2912250685 creator A5000005180 @default.
• W2912250685 creator A5015937284 @default.
• W2912250685 creator A5027352987 @default.
• W2912250685 creator A5028298545 @default.
• W2912250685 creator A5045168565 @default.
• W2912250685 creator A5087691179 @default.
• W2912250685 date "2019-02-12" @default.
• W2912250685 modified "2023-10-03" @default.
• W2912250685 title "Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers" @default.
• W2912250685 cites W1963878229 @default.
• W2912250685 cites W1978158433 @default.
• W2912250685 cites W1983658862 @default.
• W2912250685 cites W1989475021 @default.
• W2912250685 cites W1990986005 @default.
• W2912250685 cites W2005895632 @default.
• W2912250685 cites W2009628240 @default.
• W2912250685 cites W2011924190 @default.
• W2912250685 cites W2021536610 @default.
• W2912250685 cites W2034115849 @default.
• W2912250685 cites W2039576757 @default.
• W2912250685 cites W2043798203 @default.
• W2912250685 cites W2057319734 @default.
• W2912250685 cites W2071457560 @default.
• W2912250685 cites W2078505025 @default.
• W2912250685 cites W2086777866 @default.
• W2912250685 cites W2095595090 @default.
• W2912250685 cites W2096910745 @default.
• W2912250685 cites W2119055722 @default.
• W2912250685 cites W2123734813 @default.
• W2912250685 cites W2124820482 @default.
• W2912250685 cites W2125370645 @default.
• W2912250685 cites W2130649080 @default.
• W2912250685 cites W2133106304 @default.
• W2912250685 cites W2151918127 @default.
• W2912250685 cites W2159290008 @default.
• W2912250685 cites W2161062193 @default.
• W2912250685 cites W2161696602 @default.
• W2912250685 cites W2162723598 @default.
• W2912250685 cites W2162923414 @default.
• W2912250685 cites W2177777322 @default.
• W2912250685 cites W2296031005 @default.
• W2912250685 cites W2346285130 @default.
• W2912250685 cites W2471011913 @default.
• W2912250685 cites W2580220347 @default.
• W2912250685 cites W2622700789 @default.
• W2912250685 cites W2745330422 @default.
• W2912250685 cites W2806421539 @default.
• W2912250685 doi "https://doi.org/10.1007/s10549-018-05113-8" @default.
• W2912250685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6491658" @default.
• W2912250685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30746633" @default.
• W2912250685 hasPublicationYear "2019" @default.
• W2912250685 type Work @default.
• W2912250685 sameAs 2912250685 @default.
• W2912250685 citedByCount "8" @default.
• W2912250685 countsByYear W29122506852020 @default.
• W2912250685 countsByYear W29122506852021 @default.
• W2912250685 countsByYear W29122506852022 @default.
• W2912250685 crossrefType "journal-article" @default.
• W2912250685 hasAuthorship W2912250685A5000005180 @default.
• W2912250685 hasAuthorship W2912250685A5015937284 @default.
• W2912250685 hasAuthorship W2912250685A5027352987 @default.
• W2912250685 hasAuthorship W2912250685A5028298545 @default.
• W2912250685 hasAuthorship W2912250685A5045168565 @default.
• W2912250685 hasAuthorship W2912250685A5087691179 @default.
• W2912250685 hasBestOaLocation W29122506851 @default.
• W2912250685 hasConcept C121608353 @default.
• W2912250685 hasConcept C126322002 @default.
• W2912250685 hasConcept C143425029 @default.
• W2912250685 hasConcept C184235292 @default.
• W2912250685 hasConcept C2779486608 @default.
• W2912250685 hasConcept C502942594 @default.
• W2912250685 hasConcept C530470458 @default.
• W2912250685 hasConcept C54355233 @default.
• W2912250685 hasConcept C552990157 @default.
• W2912250685 hasConcept C71924100 @default.
• W2912250685 hasConcept C86803240 @default.
• W2912250685 hasConceptScore W2912250685C121608353 @default.
• W2912250685 hasConceptScore W2912250685C126322002 @default.
• W2912250685 hasConceptScore W2912250685C143425029 @default.
• W2912250685 hasConceptScore W2912250685C184235292 @default.
• W2912250685 hasConceptScore W2912250685C2779486608 @default.
• W2912250685 hasConceptScore W2912250685C502942594 @default.
• W2912250685 hasConceptScore W2912250685C530470458 @default.
• W2912250685 hasConceptScore W2912250685C54355233 @default.
• W2912250685 hasConceptScore W2912250685C552990157 @default.
• W2912250685 hasConceptScore W2912250685C71924100 @default.
• W2912250685 hasConceptScore W2912250685C86803240 @default.
• W2912250685 hasIssue "1" @default.
• W2912250685 hasLocation W29122506851 @default.
• W2912250685 hasLocation W29122506852 @default.
• W2912250685 hasLocation W29122506853 @default.
• W2912250685 hasLocation W29122506854 @default.
• W2912250685 hasLocation W29122506855 @default.
• W2912250685 hasOpenAccess W2912250685 @default.
• W2912250685 hasPrimaryLocation W29122506851 @default.
• W2912250685 hasRelatedWork W1526050073 @default.

• next