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• W2912259266 abstract "Platinum(II) complexes with different cinnamic acid derivatives as ligands were investigated for their ability to inhibit the aggregation process of amyloid systems derived from Aβ, Yeast Prion Protein Sup35p and the C-terminal domain of nucleophosmin 1. Thioflavin T binding assays and circular dichroism data indicate that these compounds strongly inhibit the aggregation of investigated peptides exhibiting IC50 values in the micromolar range. MS analysis confirms the formation of adducts between peptides and Pt(II) complexes that are also able to reduce amyloid cytotoxicity in human SH-SY5Y neuroblastoma cells. Overall data suggests that bidentate ligands based on β-hydroxy dithiocinnamic esters can be used to develop platinum or platinoid compounds with anti-amyloid aggregation properties." @default.
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• W2912259266 date "2019-02-14" @default.
• W2912259266 modified "2023-10-17" @default.
• W2912259266 title "Platinum(II) O,S Complexes Inhibit the Aggregation of Amyloid Model Systems" @default.
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• W2912259266 doi "https://doi.org/10.3390/ijms20040829" @default.
• W2912259266 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6413125" @default.
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