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• W2912262476 endingPage "274" @default.
• W2912262476 startingPage "263" @default.
• W2912262476 abstract "Accelerated neurological disorders are increasingly prominent among the HIV-infected population and are likely driven by the toxicity from long-term use of antiretroviral drugs. We explored potential side effects of antiretroviral drugs in HIV-infected primary human astrocytes and whether opioid co-exposure exacerbates the response. HIV-infected human astrocytes were exposed to the reverse transcriptase inhibitor, emtricitabine, alone or in combination with two protease inhibitors ritonavir and atazanavir (ERA) with and without morphine co-exposure. The effect of the protease inhibitor, lopinavir, alone or in combination with the protease inhibitor, abacavir, and the integrase inhibitor, raltegravir (LAR), with and without morphine co-exposure was also explored. Exposure with emtricitabine alone or ERA in HIV-infected astrocytes caused a significant decrease in viral replication and attenuated HIV-induced inflammatory molecules, while co-exposure with morphine negated the inhibitory effects of ERA, leading to increased viral replication and inflammatory molecules. Exposure with emtricitabine alone or in combination with morphine caused a significant disruption of mitochondrial membrane integrity. Genetic analysis revealed a significant increase in the expression of p62/SQSTM1 which correlated with an increase in the histone-modifying enzyme, ESCO2, after exposure with ERA alone or in combination with morphine. Furthermore, several histone-modifying enzymes such as CIITA, PRMT8, and HDAC10 were also increased with LAR exposure alone or in combination with morphine. Accumulation of p62/SQSTM1 is indicative of dysfunctional lysosomal fusion. Together with the loss of mitochondrial integrity and epigenetic changes, these effects may lead to enhanced viral titer and inflammatory molecules contributing to the neuropathology associated with HIV." @default.
• W2912262476 created "2019-02-21" @default.
• W2912262476 creator A5000297941 @default.
• W2912262476 creator A5016700147 @default.
• W2912262476 creator A5032278927 @default.
• W2912262476 creator A5042159116 @default.
• W2912262476 creator A5063715894 @default.
• W2912262476 creator A5070895279 @default.
• W2912262476 creator A5085307311 @default.
• W2912262476 date "2019-02-11" @default.
• W2912262476 modified "2023-10-18" @default.
• W2912262476 title "Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone-modifying enzymes in HIV-infected astrocytes" @default.
• W2912262476 cites W1499984715 @default.
• W2912262476 cites W1538481625 @default.
• W2912262476 cites W1573558157 @default.
• W2912262476 cites W1605613258 @default.
• W2912262476 cites W1757008411 @default.
• W2912262476 cites W1805322877 @default.
• W2912262476 cites W1965786497 @default.
• W2912262476 cites W1967548282 @default.
• W2912262476 cites W1974682327 @default.
• W2912262476 cites W1976434061 @default.
• W2912262476 cites W1977121504 @default.
• W2912262476 cites W1978724449 @default.
• W2912262476 cites W1981648285 @default.
• W2912262476 cites W1983240538 @default.
• W2912262476 cites W1987951773 @default.
• W2912262476 cites W1996809518 @default.
• W2912262476 cites W1998529637 @default.
• W2912262476 cites W1999544109 @default.
• W2912262476 cites W2000460634 @default.
• W2912262476 cites W2001790634 @default.
• W2912262476 cites W2004829503 @default.
• W2912262476 cites W2007607803 @default.
• W2912262476 cites W2008735323 @default.
• W2912262476 cites W2010804532 @default.
• W2912262476 cites W2011823893 @default.
• W2912262476 cites W2013733751 @default.
• W2912262476 cites W2014285566 @default.
• W2912262476 cites W2014697109 @default.
• W2912262476 cites W2018102225 @default.
• W2912262476 cites W2024643363 @default.
• W2912262476 cites W2025214951 @default.
• W2912262476 cites W2028660101 @default.
• W2912262476 cites W2031089158 @default.
• W2912262476 cites W2031849354 @default.
• W2912262476 cites W2055432326 @default.
• W2912262476 cites W2055579254 @default.
• W2912262476 cites W2064581549 @default.
• W2912262476 cites W2067002444 @default.
• W2912262476 cites W2067036095 @default.
• W2912262476 cites W2070381032 @default.
• W2912262476 cites W2077813547 @default.
• W2912262476 cites W2079777665 @default.
• W2912262476 cites W2081088289 @default.
• W2912262476 cites W2085610247 @default.
• W2912262476 cites W2085879736 @default.
• W2912262476 cites W2087579640 @default.
• W2912262476 cites W2098548022 @default.
• W2912262476 cites W2100634038 @default.
• W2912262476 cites W2102336941 @default.
• W2912262476 cites W2106245879 @default.
• W2912262476 cites W2107114877 @default.
• W2912262476 cites W2109169003 @default.
• W2912262476 cites W2111757377 @default.
• W2912262476 cites W2115719856 @default.
• W2912262476 cites W2115837402 @default.
• W2912262476 cites W2116412678 @default.
• W2912262476 cites W2120046850 @default.
• W2912262476 cites W2122044177 @default.
• W2912262476 cites W2122341467 @default.
• W2912262476 cites W2126516300 @default.
• W2912262476 cites W2131880270 @default.
• W2912262476 cites W2135048849 @default.
• W2912262476 cites W2135096349 @default.
• W2912262476 cites W2135520652 @default.
• W2912262476 cites W2141815936 @default.
• W2912262476 cites W2152356908 @default.
• W2912262476 cites W2154076020 @default.
• W2912262476 cites W2167686653 @default.
• W2912262476 cites W2169095774 @default.
• W2912262476 cites W2233854610 @default.
• W2912262476 cites W2273184168 @default.
• W2912262476 cites W2287627428 @default.
• W2912262476 cites W2314126070 @default.
• W2912262476 cites W2315808400 @default.
• W2912262476 cites W2407578345 @default.
• W2912262476 cites W2417755293 @default.
• W2912262476 cites W2472278904 @default.
• W2912262476 cites W2524894692 @default.
• W2912262476 cites W2550071890 @default.
• W2912262476 cites W2739884031 @default.
• W2912262476 cites W2748440687 @default.
• W2912262476 cites W2774433341 @default.
• W2912262476 cites W2800519954 @default.
• W2912262476 cites W2801503709 @default.
• W2912262476 cites W3193259242 @default.
• W2912262476 cites W4237449074 @default.

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