FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912263218> ?p ?o ?g. }

• W2912263218 endingPage "C491" @default.
• W2912263218 startingPage "C481" @default.
• W2912263218 abstract "The inadequate trophoblast invasion is associated with the development of preeclampsia (PE). Considering that annexin A4 (ANXA4) enhances tumor invasion, we aimed to explore the functional role of ANXA4 in trophoblast cells and to examine the underlying mechanism. ANXA4 expression in PE placentas was analyzed using immunohistochemistry and Western blotting. Cell proliferation, invasion, and apoptosis were determined using a MTT assay, Transwell assay, and flow cytometry, respectively. The expression levels of matrix metalloproteinase (MMP)-2, MMP-9, phosphoinositide 3-kinase (PI3K), Akt, phosphorylated (p)-Akt, and phosphorylated endothelial nitric oxide synthase (p-eNOS) were detected by Western blotting. Placentas were prepared for pathological examination using hematoxylin and eosin staining and apoptosis determination using the TUNEL method. Expression of ANXA4, PI3K, p-Akt and p-eNOS was downregulated in human PE placentas and PE placenta-derived extravillous cytotrophoblasts (EVCTs). Furthermore, ANXA4 overexpression promoted cell proliferation and invasion, inhibited cell apoptosis, and upregulated protein expression of PI3K, p-Akt, and p-eNOS in human trophoblast cells HTR-8/SVneo and JEG-3. By contrast, ANXA4 knockdown exerted the opposite effects. Furthermore, inhibition of the PI3K/Akt pathway by LY294002 abrogated the ANXA4 overexpression-mediated effects on trophoblast behavior. Furthermore, eNOS knockdown abrogated the ANXA4 overexpression-induced promotion of cell invasion and MMP2/9 expression. Additionally, in N-nitro-l-arginine methyl ester (l-NAME)-induced PE rats, ANXA4 overexpression alleviated PE progression, accompanied by an increase in expression of PI3K, p-Akt, and p-eNOS in rat placentas. Our findings demonstrate that ANXA4 expression is downregulated in PE. ANXA4 may promote trophoblast invasion via the PI3K/Akt/eNOS pathway." @default.
• W2912263218 created "2019-02-21" @default.
• W2912263218 creator A5008199212 @default.
• W2912263218 creator A5010934355 @default.
• W2912263218 creator A5027731868 @default.
• W2912263218 creator A5033463518 @default.
• W2912263218 creator A5050278993 @default.
• W2912263218 creator A5056627707 @default.
• W2912263218 date "2019-04-01" @default.
• W2912263218 modified "2023-10-14" @default.
• W2912263218 title "ANXA4 promotes trophoblast invasion via the PI3K/Akt/eNOS pathway in preeclampsia" @default.
• W2912263218 cites W1910265541 @default.
• W2912263218 cites W1984970610 @default.
• W2912263218 cites W1986270064 @default.
• W2912263218 cites W1991833468 @default.
• W2912263218 cites W2010304520 @default.
• W2912263218 cites W2016486859 @default.
• W2912263218 cites W2018078168 @default.
• W2912263218 cites W2034947575 @default.
• W2912263218 cites W2044692553 @default.
• W2912263218 cites W2065456584 @default.
• W2912263218 cites W2074655501 @default.
• W2912263218 cites W2096085246 @default.
• W2912263218 cites W2102916843 @default.
• W2912263218 cites W2223422228 @default.
• W2912263218 cites W2283592182 @default.
• W2912263218 cites W2322863646 @default.
• W2912263218 cites W2324187112 @default.
• W2912263218 cites W2463245767 @default.
• W2912263218 cites W2504599721 @default.
• W2912263218 cites W2516552398 @default.
• W2912263218 cites W2525936032 @default.
• W2912263218 cites W2577161566 @default.
• W2912263218 cites W2625314850 @default.
• W2912263218 cites W2737370938 @default.
• W2912263218 cites W2804190340 @default.
• W2912263218 cites W3021099373 @default.
• W2912263218 cites W4211051919 @default.
• W2912263218 cites W656848795 @default.
• W2912263218 doi "https://doi.org/10.1152/ajpcell.00404.2018" @default.
• W2912263218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30673304" @default.
• W2912263218 hasPublicationYear "2019" @default.
• W2912263218 type Work @default.
• W2912263218 sameAs 2912263218 @default.
• W2912263218 citedByCount "59" @default.
• W2912263218 countsByYear W29122632182019 @default.
• W2912263218 countsByYear W29122632182020 @default.
• W2912263218 countsByYear W29122632182021 @default.
• W2912263218 countsByYear W29122632182022 @default.
• W2912263218 countsByYear W29122632182023 @default.
• W2912263218 crossrefType "journal-article" @default.
• W2912263218 hasAuthorship W2912263218A5008199212 @default.
• W2912263218 hasAuthorship W2912263218A5010934355 @default.
• W2912263218 hasAuthorship W2912263218A5027731868 @default.
• W2912263218 hasAuthorship W2912263218A5033463518 @default.
• W2912263218 hasAuthorship W2912263218A5050278993 @default.
• W2912263218 hasAuthorship W2912263218A5056627707 @default.
• W2912263218 hasBestOaLocation W29122632181 @default.
• W2912263218 hasConcept C104317684 @default.
• W2912263218 hasConcept C11960822 @default.
• W2912263218 hasConcept C127561419 @default.
• W2912263218 hasConcept C134018914 @default.
• W2912263218 hasConcept C153911025 @default.
• W2912263218 hasConcept C16685009 @default.
• W2912263218 hasConcept C172680121 @default.
• W2912263218 hasConcept C173396325 @default.
• W2912263218 hasConcept C185592680 @default.
• W2912263218 hasConcept C190283241 @default.
• W2912263218 hasConcept C2776953305 @default.
• W2912263218 hasConcept C2777495146 @default.
• W2912263218 hasConcept C2777622882 @default.
• W2912263218 hasConcept C2778326061 @default.
• W2912263218 hasConcept C2779234561 @default.
• W2912263218 hasConcept C2780699576 @default.
• W2912263218 hasConcept C502942594 @default.
• W2912263218 hasConcept C519581460 @default.
• W2912263218 hasConcept C54355233 @default.
• W2912263218 hasConcept C553184892 @default.
• W2912263218 hasConcept C55493867 @default.
• W2912263218 hasConcept C62112901 @default.
• W2912263218 hasConcept C62478195 @default.
• W2912263218 hasConcept C71924100 @default.
• W2912263218 hasConcept C75217442 @default.
• W2912263218 hasConcept C85265743 @default.
• W2912263218 hasConcept C86554907 @default.
• W2912263218 hasConcept C86803240 @default.
• W2912263218 hasConcept C88634738 @default.
• W2912263218 hasConcept C95444343 @default.
• W2912263218 hasConceptScore W2912263218C104317684 @default.
• W2912263218 hasConceptScore W2912263218C11960822 @default.
• W2912263218 hasConceptScore W2912263218C127561419 @default.
• W2912263218 hasConceptScore W2912263218C134018914 @default.
• W2912263218 hasConceptScore W2912263218C153911025 @default.
• W2912263218 hasConceptScore W2912263218C16685009 @default.
• W2912263218 hasConceptScore W2912263218C172680121 @default.
• W2912263218 hasConceptScore W2912263218C173396325 @default.
• W2912263218 hasConceptScore W2912263218C185592680 @default.
• W2912263218 hasConceptScore W2912263218C190283241 @default.

• next