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- W2912264954 abstract "The homeostasis of iron is of fundamental importance in the central nervous system (CNS) to ensure biological processes such as oxygen transport, mitochondrial respiration or myelin synthesis. Dyshomeostasis and accumulation of iron can be observed during aging and both are shared characteristics of several neurodegenerative diseases. Iron-mediated generation of reactive oxygen species (ROS) may lead to protein aggregation and cellular toxicity. The process of misfolding and aggregation of neuronal proteins such as α-synuclein, Tau, amyloid beta (Aβ), TDP-43 or SOD1 is a common hallmark of many neurodegenerative disorders and iron has been shown to facilitate protein aggregation. Thus, both, iron and aggregating proteins are proposed to amplify their detrimental effects in the disease state. In this review, we give an overview on effects of iron on aggregation of different proteins involved in neurodegeneration. Furthermore, we discuss the proposed mechanisms of iron-mediated toxicity and protein aggregation emphasizing the red-ox chemistry and protein-binding properties of iron. Finally, we address current therapeutic approaches harnessing iron chelation as a disease-modifying intervention in neurodegenerative disorders, such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis." @default.
- W2912264954 created "2019-02-21" @default.
- W2912264954 creator A5003936132 @default.
- W2912264954 creator A5024577973 @default.
- W2912264954 creator A5053690690 @default.
- W2912264954 creator A5057435795 @default.
- W2912264954 date "2019-01-22" @default.
- W2912264954 modified "2023-10-17" @default.
- W2912264954 title "The Contribution of Iron to Protein Aggregation Disorders in the Central Nervous System" @default.
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