Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912265581> ?p ?o ?g. }
- W2912265581 endingPage "e6352" @default.
- W2912265581 startingPage "e6352" @default.
- W2912265581 abstract "ZBTB38 belongs to the zinc finger protein family and contains the typical BTB domains. As a transcription factor, ZBTB38 is involved in cell regulation, proliferation and apoptosis, whereas, functional deficiency of ZBTB38 induces the human neuroblastoma (NB) cell death potentially. To have some insight into the role of ZBTB38 in NB development, high throughput RNA sequencing was performed using the human NB cell line SH-SY5Y with the deletion of ZBTB38. In the present study, 2,438 differentially expressed genes (DEGs) in ZBTB38 −/− SH-SY5Y cells were obtained, 83.5% of which was down-regulated. Functional annotation of the DEGs in the Kyoto Encyclopedia of Genes and Genomes database revealed that most of the identified genes were enriched in the neurotrophin TRK receptor signaling pathway, including PI3K/Akt and MAPK signaling pathway. we also observed that ZBTB38 affects expression of CDK4/6, Cyclin E, MDM2, ATM, ATR, PTEN, Gadd45, and PIGs in the p53 signaling pathway. In addition, ZBTB38 knockdown significantly suppresses the expression of autophagy-related key genes including PIK3C2A and RB1CC1. The present meeting provides evidence to molecular mechanism of ZBTB38 modulating NB development and targeted anti-tumor therapies." @default.
- W2912265581 created "2019-02-21" @default.
- W2912265581 creator A5001394657 @default.
- W2912265581 creator A5004082085 @default.
- W2912265581 creator A5013327648 @default.
- W2912265581 creator A5014578404 @default.
- W2912265581 creator A5025502521 @default.
- W2912265581 creator A5027835055 @default.
- W2912265581 creator A5043148241 @default.
- W2912265581 creator A5045549865 @default.
- W2912265581 creator A5062901800 @default.
- W2912265581 creator A5063768510 @default.
- W2912265581 creator A5087410874 @default.
- W2912265581 date "2019-01-24" @default.
- W2912265581 modified "2023-10-17" @default.
- W2912265581 title "Transcriptome profiling reveals the role of ZBTB38 knock-down in human neuroblastoma" @default.
- W2912265581 cites W1918384196 @default.
- W2912265581 cites W1974116356 @default.
- W2912265581 cites W1974867401 @default.
- W2912265581 cites W1976589764 @default.
- W2912265581 cites W1981509058 @default.
- W2912265581 cites W1989234053 @default.
- W2912265581 cites W1991660531 @default.
- W2912265581 cites W2004067791 @default.
- W2912265581 cites W2010799818 @default.
- W2912265581 cites W2019768326 @default.
- W2912265581 cites W2022775759 @default.
- W2912265581 cites W2023245305 @default.
- W2912265581 cites W2031983198 @default.
- W2912265581 cites W2032167680 @default.
- W2912265581 cites W2035364743 @default.
- W2912265581 cites W2041313118 @default.
- W2912265581 cites W2042666427 @default.
- W2912265581 cites W2043977836 @default.
- W2912265581 cites W2054646144 @default.
- W2912265581 cites W2062674518 @default.
- W2912265581 cites W2074730941 @default.
- W2912265581 cites W2084290067 @default.
- W2912265581 cites W2084650850 @default.
- W2912265581 cites W2087374769 @default.
- W2912265581 cites W2087751835 @default.
- W2912265581 cites W2093773476 @default.
- W2912265581 cites W2096979580 @default.
- W2912265581 cites W2102353246 @default.
- W2912265581 cites W2105106534 @default.
- W2912265581 cites W2105371278 @default.
- W2912265581 cites W2107060225 @default.
- W2912265581 cites W2110817748 @default.
- W2912265581 cites W2113370608 @default.
- W2912265581 cites W2114104545 @default.
- W2912265581 cites W2118167354 @default.
- W2912265581 cites W2119923823 @default.
- W2912265581 cites W2121016876 @default.
- W2912265581 cites W2123060905 @default.
- W2912265581 cites W2124985265 @default.
- W2912265581 cites W2127963635 @default.
- W2912265581 cites W2128252882 @default.
- W2912265581 cites W2129364443 @default.
- W2912265581 cites W2131393200 @default.
- W2912265581 cites W2135449289 @default.
- W2912265581 cites W2140729960 @default.
- W2912265581 cites W2152239989 @default.
- W2912265581 cites W2152556446 @default.
- W2912265581 cites W2159956236 @default.
- W2912265581 cites W2178678422 @default.
- W2912265581 cites W2301120951 @default.
- W2912265581 cites W2411244835 @default.
- W2912265581 cites W2462769577 @default.
- W2912265581 cites W2593816418 @default.
- W2912265581 cites W2608493286 @default.
- W2912265581 cites W2626202887 @default.
- W2912265581 cites W2769198083 @default.
- W2912265581 cites W4232865341 @default.
- W2912265581 doi "https://doi.org/10.7717/peerj.6352" @default.
- W2912265581 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6348090" @default.
- W2912265581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30697495" @default.
- W2912265581 hasPublicationYear "2019" @default.
- W2912265581 type Work @default.
- W2912265581 sameAs 2912265581 @default.
- W2912265581 citedByCount "6" @default.
- W2912265581 countsByYear W29122655812020 @default.
- W2912265581 countsByYear W29122655812021 @default.
- W2912265581 countsByYear W29122655812022 @default.
- W2912265581 crossrefType "journal-article" @default.
- W2912265581 hasAuthorship W2912265581A5001394657 @default.
- W2912265581 hasAuthorship W2912265581A5004082085 @default.
- W2912265581 hasAuthorship W2912265581A5013327648 @default.
- W2912265581 hasAuthorship W2912265581A5014578404 @default.
- W2912265581 hasAuthorship W2912265581A5025502521 @default.
- W2912265581 hasAuthorship W2912265581A5027835055 @default.
- W2912265581 hasAuthorship W2912265581A5043148241 @default.
- W2912265581 hasAuthorship W2912265581A5045549865 @default.
- W2912265581 hasAuthorship W2912265581A5062901800 @default.
- W2912265581 hasAuthorship W2912265581A5063768510 @default.
- W2912265581 hasAuthorship W2912265581A5087410874 @default.
- W2912265581 hasBestOaLocation W29122655811 @default.
- W2912265581 hasConcept C104317684 @default.
- W2912265581 hasConcept C150194340 @default.