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- W2912266058 abstract "Eicosanoids are fatty acid oxides which are metabolized from arachidonic acids by oxidase such as cyclooxygenase (COX), lipoxygenase (LOX), and epoxygenase, and it has been known that the abnormal activation of arachidonic pathway is association with the occurrence of asthma. We aimed to identify novel effective metabolite marker that distinguish refractory asthma and find out the etiology of refractory asthma. Peripheral blood was obtained from 4 subjects of control group, 56 subjects with non-refractory asthma, and 48 subjects with refractory asthma. Refractory asthma was defined as asthma that requires treatment with high dose inhaled corticosteroids to control, and when patients had two or more acute exacerbations within 12 months, or persistent decreased lung function (predicted value of forced expiratory volume in 1 second<80%). Simultaneous measurements of 43 multiple eicosanoid biomarker panels were performed using liquid chromatography(LC)-mass spectrometry(MS)/MS analysis. Among 42 eicosanoids, the mean levels of PGJ2 (p=0.035), LTB4 (p=0.009), S5HETE (p=0.002), 5-oxo-ETE (p=0.005), 12-oxo-ETE (p=0.006), and LXA4 (p=0.008) were significantly increased in refractory asthma group than in non-refractory asthma group. Among 48 refractory asthmatics, 36 showed frequent exacerbations and 26 showed airway remodeling. The former 6 eicosanoids were increased in frequent exacerbation group, while patients with airway remodeling showed no difference in any eicosanoid. In non-refractory asthma group, the presence of atopy increased the level of 6 eicosanoids. Eicosanoids metabolized by LOX and COX pathway were increased in refractory asthmatics, especially in frequent exacerbators. Increased eicosanoids in non-atopic asthmatics may be a predictor of frequent exacerbation." @default.
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- W2912266058 date "2019-02-01" @default.
- W2912266058 modified "2023-10-11" @default.
- W2912266058 title "Novel Plasma Metabolite Markers From Arachidonic Acid Pathway For Distinguishing Refractory Asthma." @default.
- W2912266058 doi "https://doi.org/10.1016/j.jaci.2018.12.908" @default.
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