FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912266069> ?p ?o ?g. }

• W2912266069 endingPage "926" @default.
• W2912266069 startingPage "917" @default.
• W2912266069 abstract "Organic nanoparticles offer the advantage of high biocompatibility for biomedical applications but suffer frequently from poor visibility in biological environments. While fluorescent-labeling is convenient and allows for fast and extensive histological analysis, fluorescence imaging and quantitative analysis are limited by low resolution and significantly hindered by tissue autofluorescence. Labeling of polymeric nanoparticles with an additional gold tag would allow for high resolution imaging via transmission electron microscopy (TEM) and for quantification of particles by inductively coupled plasma optical emission spectrometry (ICP-OES). However, spatially uncontrolled gold-tagging can cause significant fluorescence quenching. To overcome this restraint, 2.2 nm gold nanoparticles were introduced at the interface between the hydrophobic fluorophore-loaded core and the hydrophilic shell of polymeric nanoparticles. Due to the small size of gold labels and the spatially controlled stratified composition of hybrid nanoparticles, fluorescence quenching by gold tags was minimized to 15.1%, allowing for concomitant detection of both labels via optical microscopy after enhancement of the gold tags. Multilayered hybrid nanoparticles exhibited outstanding detectability in TEM, even without additional sample staining. Furthermore, they were capable of producing remarkable image contrast inside cells after gold or silver enhancement. The interfacial gold layer increased the hydrodynamic particle size only marginally from 71.8 to 89.5 nm and had no negative impact on biocompatibility in vitro. The gold content (0.75% m/m) is sufficiently high for future quantification in tissues after systemic administration. With their clean-cut structure and superior detectability, multilayered hybrid nanoparticles constitute an outstanding blueprint and a precious tool for the development of nanomedicines." @default.
• W2912266069 created "2019-02-21" @default.
• W2912266069 creator A5005822241 @default.
• W2912266069 creator A5037981388 @default.
• W2912266069 creator A5076937125 @default.
• W2912266069 creator A5086220716 @default.
• W2912266069 date "2019-01-24" @default.
• W2912266069 modified "2023-10-03" @default.
• W2912266069 title "Gold-Tagged Polymeric Nanoparticles with Spatially Controlled Composition for Enhanced Detectability in Biological Environments" @default.
• W2912266069 cites W1964400351 @default.
• W2912266069 cites W1966846263 @default.
• W2912266069 cites W1970838842 @default.
• W2912266069 cites W1977406946 @default.
• W2912266069 cites W1980751351 @default.
• W2912266069 cites W1984227686 @default.
• W2912266069 cites W1986547299 @default.
• W2912266069 cites W1989485130 @default.
• W2912266069 cites W1991032925 @default.
• W2912266069 cites W1992031451 @default.
• W2912266069 cites W1994265576 @default.
• W2912266069 cites W1998996122 @default.
• W2912266069 cites W2005688834 @default.
• W2912266069 cites W2013324427 @default.
• W2912266069 cites W2019555018 @default.
• W2912266069 cites W2022646304 @default.
• W2912266069 cites W2032263279 @default.
• W2912266069 cites W2035530997 @default.
• W2912266069 cites W2042519261 @default.
• W2912266069 cites W2043322419 @default.
• W2912266069 cites W2044794349 @default.
• W2912266069 cites W2055213233 @default.
• W2912266069 cites W2057632167 @default.
• W2912266069 cites W2067002802 @default.
• W2912266069 cites W2068159484 @default.
• W2912266069 cites W2069009184 @default.
• W2912266069 cites W2071636590 @default.
• W2912266069 cites W2073919974 @default.
• W2912266069 cites W2074949050 @default.
• W2912266069 cites W2079039911 @default.
• W2912266069 cites W2082459172 @default.
• W2912266069 cites W2087032263 @default.
• W2912266069 cites W2100396234 @default.
• W2912266069 cites W2116986583 @default.
• W2912266069 cites W2122149837 @default.
• W2912266069 cites W2126055489 @default.
• W2912266069 cites W2128958387 @default.
• W2912266069 cites W2130052270 @default.
• W2912266069 cites W2144907950 @default.
• W2912266069 cites W2161004176 @default.
• W2912266069 cites W2162858952 @default.
• W2912266069 cites W2164195061 @default.
• W2912266069 cites W2169689625 @default.
• W2912266069 cites W2169799888 @default.
• W2912266069 cites W2296645551 @default.
• W2912266069 cites W2315821832 @default.
• W2912266069 cites W2334244078 @default.
• W2912266069 cites W2557458575 @default.
• W2912266069 cites W2622388056 @default.
• W2912266069 cites W2791089732 @default.
• W2912266069 cites W2902706607 @default.
• W2912266069 cites W2902719982 @default.
• W2912266069 cites W2907971690 @default.
• W2912266069 cites W3022160526 @default.
• W2912266069 cites W88447590 @default.
• W2912266069 doi "https://doi.org/10.1021/acsanm.8b02165" @default.
• W2912266069 hasPublicationYear "2019" @default.
• W2912266069 type Work @default.
• W2912266069 sameAs 2912266069 @default.
• W2912266069 citedByCount "6" @default.
• W2912266069 countsByYear W29122660692020 @default.
• W2912266069 countsByYear W29122660692022 @default.
• W2912266069 countsByYear W29122660692023 @default.
• W2912266069 crossrefType "journal-article" @default.
• W2912266069 hasAuthorship W2912266069A5005822241 @default.
• W2912266069 hasAuthorship W2912266069A5037981388 @default.
• W2912266069 hasAuthorship W2912266069A5076937125 @default.
• W2912266069 hasAuthorship W2912266069A5086220716 @default.
• W2912266069 hasConcept C104819515 @default.
• W2912266069 hasConcept C113196181 @default.
• W2912266069 hasConcept C120665830 @default.
• W2912266069 hasConcept C121332964 @default.
• W2912266069 hasConcept C121745418 @default.
• W2912266069 hasConcept C146088050 @default.
• W2912266069 hasConcept C147080431 @default.
• W2912266069 hasConcept C155672457 @default.
• W2912266069 hasConcept C171250308 @default.
• W2912266069 hasConcept C179687394 @default.
• W2912266069 hasConcept C185592680 @default.
• W2912266069 hasConcept C191897082 @default.
• W2912266069 hasConcept C192562407 @default.
• W2912266069 hasConcept C2777230088 @default.
• W2912266069 hasConcept C2778617687 @default.
• W2912266069 hasConcept C43617362 @default.
• W2912266069 hasConcept C91881484 @default.
• W2912266069 hasConceptScore W2912266069C104819515 @default.
• W2912266069 hasConceptScore W2912266069C113196181 @default.
• W2912266069 hasConceptScore W2912266069C120665830 @default.
• W2912266069 hasConceptScore W2912266069C121332964 @default.

• next