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- W2912267294 abstract "Aim: Evaluation of solid lipid nanoparticles (SLNs) for ocular delivery of isoniazid (INH). Materials & methods: INH-SLNs were characterized for morphological, thermal, crystalline and nuclear magnetic resonance properties. In vitro release and ex vivo corneal permeability of INH-SLNs was also evaluated. Proof-of-concept uptake studies were performed in corneal and conjunctival cell lines and in vivo in rat eye using fluorescein-labeled SLNs. Antimycobacterial activity of INH-SLNs was confirmed. In vivo aqueous humor pharmacokinetics, toxicity and tolerance was performed in rabbit/rat eye. Results: INH-SLNs showed extended release (48 h), enhanced corneal permeability (1.6-times), five-times lower MIC, significant in vitro and in vivo uptake of fluorescein-labeled SLNs, 4.2-times ocular bioavailability (area under the curve) and in vivo acute and repeat dose safety. Conclusion: INH-SLNs are an effective ocular delivery system." @default.
- W2912267294 created "2019-02-21" @default.
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- W2912267294 date "2019-02-01" @default.
- W2912267294 modified "2023-10-09" @default.
- W2912267294 title "Solid lipid nanoparticles for ocular delivery of isoniazid: evaluation, proof of concept and <i>in vivo</i> safety & kinetics" @default.
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- W2912267294 doi "https://doi.org/10.2217/nnm-2018-0278" @default.
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