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- W2912268620 abstract "Table: Adalimumab Efficacy Over Time in Patients With Luminal CDPurpose: We evaluated the long-term efficacy and safety of adalimumab, a fully human monoclonal antibody against the tumor necrosis factor (TNF-α), in the induction of clinical remission/response in patients with moderately to severely active Crohn's disease who lost response or showed intolerance to infliximab. Methods: In this observational open-label multi-centre, prospective study, patients with moderate to severely active Crohn's disease (CDAI > 220) who had lost response or showed intolerance to infliximab were treated with subcutaneous adalimumab: 160 mg at week 0, 80 mg at week 2, then 40 mg eow for 52 weeks. Subjects were assessed for clinical remission (CDAI < 150), clinical response (CR) 70 and CR100 (CDAI decrease of more than 70 or 100 points comparing with baseline) and safety. Results: 38 patients were recruited who had luminal Crohn's disease (10 of them luminal fistulizing). Mean duration of CD was 8.8 ± 5.2 years. At baseline, 55% were on AZA/6MP, 63% on corticosteroids, 42% had previous loss of response to infliximab, and 58% had developed intolerance to infliximab. The mean CDAI score at baseline was 310.7 ± 65.4. Long-term results are shown in the table. Conclusion: Adalimumab treatment was effective in inducing and maintaining long-term clinical response and clinical remission in patients with moderately to severely active luminal Crohn's disease who had lost response or showed intolerance to infliximab. No new safety concerns were found compared with other adalimumab-treated populations." @default.
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- W2912268620 date "2007-09-01" @default.
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- W2912268620 title "Long-Term Efficacy of Adalimumab Treatment in Patients with Moderately to Severely Active Luminal Crohnʼs Disease Who Lost Response or Showed Intolerance to Infliximab" @default.
- W2912268620 doi "https://doi.org/10.14309/00000434-200709002-01033" @default.
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