Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912269007> ?p ?o ?g. }
- W2912269007 endingPage "945.e4" @default.
- W2912269007 startingPage "930" @default.
- W2912269007 abstract "R-loops are three-stranded nucleic acid structures that form during transcription, especially over unmethylated CpG-rich promoters of active genes. In mouse embryonic stem cells (mESCs), CpG-rich developmental regulator genes are repressed by the Polycomb complexes PRC1 and PRC2. Here, we show that R-loops form at a subset of Polycomb target genes, and we investigate their contribution to Polycomb repression. At R-loop-positive genes, R-loop removal leads to decreased PRC1 and PRC2 recruitment and Pol II activation into a productive elongation state, accompanied by gene derepression at nascent and processed transcript levels. Stable removal of PRC2 derepresses R-loop-negative genes, as expected, but does not affect R-loops, PRC1 recruitment, or transcriptional repression of R-loop-positive genes. Our results highlight that Polycomb repression does not occur via one mechanism but consists of different layers of repression, some of which are gene specific. We uncover that one such mechanism is mediated by an interplay between R-loops and RING1B recruitment." @default.
- W2912269007 created "2019-02-21" @default.
- W2912269007 creator A5027792221 @default.
- W2912269007 creator A5034024822 @default.
- W2912269007 creator A5052906260 @default.
- W2912269007 creator A5053760914 @default.
- W2912269007 creator A5053952380 @default.
- W2912269007 creator A5070136083 @default.
- W2912269007 date "2019-03-01" @default.
- W2912269007 modified "2023-10-15" @default.
- W2912269007 title "R-Loops Enhance Polycomb Repression at a Subset of Developmental Regulator Genes" @default.
- W2912269007 cites W1479904481 @default.
- W2912269007 cites W1658548139 @default.
- W2912269007 cites W1865495681 @default.
- W2912269007 cites W1967154926 @default.
- W2912269007 cites W1967269362 @default.
- W2912269007 cites W1967706132 @default.
- W2912269007 cites W1968931043 @default.
- W2912269007 cites W1972170164 @default.
- W2912269007 cites W1975702835 @default.
- W2912269007 cites W1975993845 @default.
- W2912269007 cites W1976736675 @default.
- W2912269007 cites W1977709885 @default.
- W2912269007 cites W1984023556 @default.
- W2912269007 cites W1989540449 @default.
- W2912269007 cites W2003719212 @default.
- W2912269007 cites W2009166526 @default.
- W2912269007 cites W2009743738 @default.
- W2912269007 cites W2010258457 @default.
- W2912269007 cites W2011181841 @default.
- W2912269007 cites W2011753829 @default.
- W2912269007 cites W2014359105 @default.
- W2912269007 cites W2017840637 @default.
- W2912269007 cites W2018865924 @default.
- W2912269007 cites W2025856640 @default.
- W2912269007 cites W2030523067 @default.
- W2912269007 cites W2038894647 @default.
- W2912269007 cites W2039289317 @default.
- W2912269007 cites W2041159570 @default.
- W2912269007 cites W2052741109 @default.
- W2912269007 cites W2054301876 @default.
- W2912269007 cites W2058890095 @default.
- W2912269007 cites W2060608189 @default.
- W2912269007 cites W2060870400 @default.
- W2912269007 cites W2062357183 @default.
- W2912269007 cites W2064261519 @default.
- W2912269007 cites W2067455706 @default.
- W2912269007 cites W2072466432 @default.
- W2912269007 cites W2077651882 @default.
- W2912269007 cites W2084699632 @default.
- W2912269007 cites W2084990854 @default.
- W2912269007 cites W2093800333 @default.
- W2912269007 cites W2095002834 @default.
- W2912269007 cites W2099564858 @default.
- W2912269007 cites W2116318886 @default.
- W2912269007 cites W2119765524 @default.
- W2912269007 cites W2124042578 @default.
- W2912269007 cites W2125761685 @default.
- W2912269007 cites W2127455821 @default.
- W2912269007 cites W2129214044 @default.
- W2912269007 cites W2131110198 @default.
- W2912269007 cites W2133938268 @default.
- W2912269007 cites W2140045506 @default.
- W2912269007 cites W2140729960 @default.
- W2912269007 cites W2148121673 @default.
- W2912269007 cites W2154968223 @default.
- W2912269007 cites W2158610627 @default.
- W2912269007 cites W2161887614 @default.
- W2912269007 cites W2170551349 @default.
- W2912269007 cites W2179299562 @default.
- W2912269007 cites W2194327633 @default.
- W2912269007 cites W2269038228 @default.
- W2912269007 cites W2340421620 @default.
- W2912269007 cites W2345850272 @default.
- W2912269007 cites W2463453322 @default.
- W2912269007 cites W2534058863 @default.
- W2912269007 cites W2553076365 @default.
- W2912269007 cites W2594707272 @default.
- W2912269007 cites W2596157468 @default.
- W2912269007 cites W2613437790 @default.
- W2912269007 cites W2754508094 @default.
- W2912269007 cites W2765629127 @default.
- W2912269007 cites W2774477523 @default.
- W2912269007 doi "https://doi.org/10.1016/j.molcel.2018.12.016" @default.
- W2912269007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6414425" @default.
- W2912269007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30709709" @default.
- W2912269007 hasPublicationYear "2019" @default.
- W2912269007 type Work @default.
- W2912269007 sameAs 2912269007 @default.
- W2912269007 citedByCount "69" @default.
- W2912269007 countsByYear W29122690072019 @default.
- W2912269007 countsByYear W29122690072020 @default.
- W2912269007 countsByYear W29122690072021 @default.
- W2912269007 countsByYear W29122690072022 @default.
- W2912269007 countsByYear W29122690072023 @default.
- W2912269007 crossrefType "journal-article" @default.
- W2912269007 hasAuthorship W2912269007A5027792221 @default.
- W2912269007 hasAuthorship W2912269007A5034024822 @default.