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• W2912269080 abstract "Background Several operative interventions are performed to reduce the mortality and morbidity of Intracerebral hemorrhage (ICH) in the acute setting, including: craniotomy or craniectomy, placement of an external ventricular drain (EVD), placement of a ventriculo-peritoneal shunt (VPS) and stereotactic craniotomy. Infections are a major source of readmissions following ICH. We explored the association between operative interventions for ICH and 30-day readmissions for infection-related causes. Methods The Nationwide Readmissions Database contains >14 million discharges for all payers and uninsured in 2013. International Classification of Disease, Ninth Revision, Clinical Modification codes were used to identify index cases of ICH, intracranial procedures, and comorbidities. We summarized demographics and comorbidities during index admission, stratified by receipt of operative interventions. We calculated differences in means (using t-tests) and frequencies (using chi-square) by group (any intervention versus none). Top 5 causes of 30-day readmission and top 5 causes for infectious readmissions were identified. Cox regression analysis was performed for time to readmission for infectious causes. Results There were 27,739 index admissions with ICH, 13% had operative interventions. In the operative group, 45.5% underwent craniotomy, 65.4% had EVD placement and 7.6% had VPS placement. Acute cerebrovascular disease was the top cause of readmission followed by infection in the entire cohort and those with interventions. Among infectious causes of readmissions, septicemia was the largest in the intervention group (65%). In both adjusted and unadjusted models, there was significant association between ICH intervention and risk of readmission for infectious causes. Among those with operative interventions for ICH, risk of readmission with infection is double the risk in the non-intervention group. Cumulative risk of readmission was higher for infection following ICH, starting after approximately 50 days, in the intervention group (log-rank p-value <.0001). Conclusions Infections and cerebrovascular complications contribute to most readmissions after ICH. There is a dose-response relationship between number of interventions and risk of infectious readmission, and this risk significantly increases after approximately 50-days." @default.
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• W2912269080 date "2019-04-01" @default.
• W2912269080 modified "2023-10-18" @default.
• W2912269080 title "Risk of readmission for infection after surgical intervention for intracerebral hemorrhage" @default.
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• W2912269080 doi "https://doi.org/10.1016/j.jns.2019.02.016" @default.
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