Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912271176> ?p ?o ?g. }
- W2912271176 endingPage "e0210971" @default.
- W2912271176 startingPage "e0210971" @default.
- W2912271176 abstract "Galectin-3 is a β-galactoside-binding lectin which is important in cell proliferation and apoptotic regulation. Recently, serum galectin-3 has been shown to have prognostic value as a biomarker in heart failure. Encephalomyocarditis virus (EMCV) can cause severe myocarditis, congestive heart failure and dilated cardiomyopathy as well as encephalitis in various animals including mice. The pathophysiological role of galectin-3 in acute myocarditis following viral infection is not fully understood. The goal of this study is to determine the cardiac localization and the time-course of galectin-3 expression in heart failure after viral inoculation with EMCV. At 12, 24, 48, 96 hours, 7 and 10 days after intraperitoneal EMCV inoculation, animals were examined histologically and analyzed for the expression of galectin-3 and Iba1. Galectin-3 was up-regulated in degenerated fibrotic lesions of cardiac tissues 96 hours after viral inoculation and were followed by myocardial fibrosis. At the same time, Iba1 positive macrophages were observed within the inflammatory sites. A time-course correlation between the number of galectin-3 positive cells and the cardiac area of degenerated fibrotic lesions was detected—serum galectin-3 increased at 96 hours and correlated well with the number of cardiac galectin-3 positive cells. Our results indicate that galectin-3 expression may be a useful biomarker of cardiac fibrotic degeneration in acute myocarditis following viral infection. In addition, measuring serum galectin-3 levels might be an early diagnostic method for detecting cardiac degeneration in acute myocarditis." @default.
- W2912271176 created "2019-02-21" @default.
- W2912271176 creator A5015424874 @default.
- W2912271176 creator A5017327924 @default.
- W2912271176 creator A5017623051 @default.
- W2912271176 creator A5031564088 @default.
- W2912271176 creator A5035875063 @default.
- W2912271176 creator A5056274903 @default.
- W2912271176 creator A5063617663 @default.
- W2912271176 creator A5086083838 @default.
- W2912271176 creator A5088170948 @default.
- W2912271176 creator A5089423258 @default.
- W2912271176 date "2019-01-23" @default.
- W2912271176 modified "2023-09-27" @default.
- W2912271176 title "Time-course analysis of cardiac and serum galectin-3 in viral myocarditis after an encephalomyocarditis virus inoculation" @default.
- W2912271176 cites W1593213689 @default.
- W2912271176 cites W1856956022 @default.
- W2912271176 cites W1893887535 @default.
- W2912271176 cites W1965498876 @default.
- W2912271176 cites W1974626393 @default.
- W2912271176 cites W2014097940 @default.
- W2912271176 cites W2014189665 @default.
- W2912271176 cites W2017005625 @default.
- W2912271176 cites W2048178709 @default.
- W2912271176 cites W2061381308 @default.
- W2912271176 cites W2074958057 @default.
- W2912271176 cites W2077989451 @default.
- W2912271176 cites W2087344026 @default.
- W2912271176 cites W2088373848 @default.
- W2912271176 cites W2121960517 @default.
- W2912271176 cites W2123248199 @default.
- W2912271176 cites W2142280282 @default.
- W2912271176 cites W2146908993 @default.
- W2912271176 cites W2151067022 @default.
- W2912271176 cites W2152064131 @default.
- W2912271176 cites W2168944137 @default.
- W2912271176 cites W2299099463 @default.
- W2912271176 cites W2522665294 @default.
- W2912271176 cites W2591717879 @default.
- W2912271176 cites W2595094108 @default.
- W2912271176 cites W2598214934 @default.
- W2912271176 cites W2615732360 @default.
- W2912271176 cites W264406207 @default.
- W2912271176 cites W2893646991 @default.
- W2912271176 cites W4234507423 @default.
- W2912271176 cites W4252859460 @default.
- W2912271176 cites W604783079 @default.
- W2912271176 cites W99989428 @default.
- W2912271176 doi "https://doi.org/10.1371/journal.pone.0210971" @default.
- W2912271176 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6343901" @default.
- W2912271176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30673749" @default.
- W2912271176 hasPublicationYear "2019" @default.
- W2912271176 type Work @default.
- W2912271176 sameAs 2912271176 @default.
- W2912271176 citedByCount "15" @default.
- W2912271176 countsByYear W29122711762020 @default.
- W2912271176 countsByYear W29122711762021 @default.
- W2912271176 countsByYear W29122711762022 @default.
- W2912271176 countsByYear W29122711762023 @default.
- W2912271176 crossrefType "journal-article" @default.
- W2912271176 hasAuthorship W2912271176A5015424874 @default.
- W2912271176 hasAuthorship W2912271176A5017327924 @default.
- W2912271176 hasAuthorship W2912271176A5017623051 @default.
- W2912271176 hasAuthorship W2912271176A5031564088 @default.
- W2912271176 hasAuthorship W2912271176A5035875063 @default.
- W2912271176 hasAuthorship W2912271176A5056274903 @default.
- W2912271176 hasAuthorship W2912271176A5063617663 @default.
- W2912271176 hasAuthorship W2912271176A5086083838 @default.
- W2912271176 hasAuthorship W2912271176A5088170948 @default.
- W2912271176 hasAuthorship W2912271176A5089423258 @default.
- W2912271176 hasBestOaLocation W29122711761 @default.
- W2912271176 hasConcept C126322002 @default.
- W2912271176 hasConcept C142724271 @default.
- W2912271176 hasConcept C156293190 @default.
- W2912271176 hasConcept C203014093 @default.
- W2912271176 hasConcept C2522874641 @default.
- W2912271176 hasConcept C2776336362 @default.
- W2912271176 hasConcept C2777420927 @default.
- W2912271176 hasConcept C2778198053 @default.
- W2912271176 hasConcept C2780559512 @default.
- W2912271176 hasConcept C2780875844 @default.
- W2912271176 hasConcept C2781197716 @default.
- W2912271176 hasConcept C2909190889 @default.
- W2912271176 hasConcept C3018763269 @default.
- W2912271176 hasConcept C55493867 @default.
- W2912271176 hasConcept C71924100 @default.
- W2912271176 hasConcept C86803240 @default.
- W2912271176 hasConceptScore W2912271176C126322002 @default.
- W2912271176 hasConceptScore W2912271176C142724271 @default.
- W2912271176 hasConceptScore W2912271176C156293190 @default.
- W2912271176 hasConceptScore W2912271176C203014093 @default.
- W2912271176 hasConceptScore W2912271176C2522874641 @default.
- W2912271176 hasConceptScore W2912271176C2776336362 @default.
- W2912271176 hasConceptScore W2912271176C2777420927 @default.
- W2912271176 hasConceptScore W2912271176C2778198053 @default.
- W2912271176 hasConceptScore W2912271176C2780559512 @default.
- W2912271176 hasConceptScore W2912271176C2780875844 @default.
- W2912271176 hasConceptScore W2912271176C2781197716 @default.