Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912271293> ?p ?o ?g. }
- W2912271293 endingPage "266" @default.
- W2912271293 startingPage "256" @default.
- W2912271293 abstract "The crucial roles played by microglia and their release of cytokines in the regulation of brain maturation are increasingly being recognized. Adolescence is a unique period characterized by continued brain maturation, especially in the area of the prefrontal cortex. Our previous studies showed that adolescent social stress induced impairment in extradimensional set-shifting (EDS), a core component of cognitive flexibility mediated by the medial prefrontal cortex (mPFC) in adult mice. The present study further determined the role of microglia and the inflammatory cytokine tumor necrosis factor alpha (TNFα) in cognitive dysfunction. Accompanied by a deficit in EDS in adulthood, previously stressed mice showed significant reductions in the expression of the microglial molecular biomarker Iba1, cell numbers, and the levels of TNFα mRNA and protein in the mPFC. Pharmacological inhibition of TNFα signaling by direct injection of a neutralizer into the mPFC also specifically impaired EDS performance. Moreover, the cognitive and immune alterations in previously stressed adult mice were ameliorated by both acute LPS and chronic antidepressant treatment. Together, our data suggest that microglia and TNFα play important roles in cognitive flexibility and can provide attractive therapeutic targets for the treatment of cognitive deficits in psychiatric disorders." @default.
- W2912271293 created "2019-02-21" @default.
- W2912271293 creator A5013767657 @default.
- W2912271293 creator A5024764279 @default.
- W2912271293 creator A5053447705 @default.
- W2912271293 creator A5071773009 @default.
- W2912271293 creator A5072918661 @default.
- W2912271293 creator A5075129009 @default.
- W2912271293 creator A5090891106 @default.
- W2912271293 date "2019-07-01" @default.
- W2912271293 modified "2023-10-10" @default.
- W2912271293 title "Deficiencies of microglia and TNFα in the mPFC-mediated cognitive inflexibility induced by social stress during adolescence" @default.
- W2912271293 cites W1073180599 @default.
- W2912271293 cites W1542136448 @default.
- W2912271293 cites W1548862642 @default.
- W2912271293 cites W1579609692 @default.
- W2912271293 cites W1767089511 @default.
- W2912271293 cites W1915977580 @default.
- W2912271293 cites W1924003686 @default.
- W2912271293 cites W1966458489 @default.
- W2912271293 cites W1977593923 @default.
- W2912271293 cites W1978891587 @default.
- W2912271293 cites W1979623781 @default.
- W2912271293 cites W1980790168 @default.
- W2912271293 cites W1982316939 @default.
- W2912271293 cites W1985925098 @default.
- W2912271293 cites W1989369404 @default.
- W2912271293 cites W1990487655 @default.
- W2912271293 cites W2003443050 @default.
- W2912271293 cites W2025743320 @default.
- W2912271293 cites W2031934728 @default.
- W2912271293 cites W2033283555 @default.
- W2912271293 cites W2036549850 @default.
- W2912271293 cites W2039717023 @default.
- W2912271293 cites W2043884992 @default.
- W2912271293 cites W2044219916 @default.
- W2912271293 cites W2050035705 @default.
- W2912271293 cites W2050961629 @default.
- W2912271293 cites W2051359369 @default.
- W2912271293 cites W2055487345 @default.
- W2912271293 cites W2057173639 @default.
- W2912271293 cites W2062363772 @default.
- W2912271293 cites W2074026676 @default.
- W2912271293 cites W2074256095 @default.
- W2912271293 cites W2076362385 @default.
- W2912271293 cites W2077761938 @default.
- W2912271293 cites W2077940341 @default.
- W2912271293 cites W2080092700 @default.
- W2912271293 cites W2084207424 @default.
- W2912271293 cites W2087146795 @default.
- W2912271293 cites W2091259554 @default.
- W2912271293 cites W2095770321 @default.
- W2912271293 cites W2099005297 @default.
- W2912271293 cites W2104827963 @default.
- W2912271293 cites W2108569388 @default.
- W2912271293 cites W2108811037 @default.
- W2912271293 cites W2110921107 @default.
- W2912271293 cites W2126795224 @default.
- W2912271293 cites W2132867079 @default.
- W2912271293 cites W2152958471 @default.
- W2912271293 cites W2160985876 @default.
- W2912271293 cites W2165860020 @default.
- W2912271293 cites W2171549018 @default.
- W2912271293 cites W2259912978 @default.
- W2912271293 cites W2326759105 @default.
- W2912271293 cites W2418601562 @default.
- W2912271293 cites W2468501494 @default.
- W2912271293 cites W2481991698 @default.
- W2912271293 cites W2504823292 @default.
- W2912271293 cites W2594610799 @default.
- W2912271293 cites W2606918206 @default.
- W2912271293 cites W2730275538 @default.
- W2912271293 cites W2757644079 @default.
- W2912271293 cites W2765644375 @default.
- W2912271293 cites W2768951700 @default.
- W2912271293 cites W2769661765 @default.
- W2912271293 cites W2776122246 @default.
- W2912271293 cites W297523562 @default.
- W2912271293 doi "https://doi.org/10.1016/j.bbi.2019.02.010" @default.
- W2912271293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30772475" @default.
- W2912271293 hasPublicationYear "2019" @default.
- W2912271293 type Work @default.
- W2912271293 sameAs 2912271293 @default.
- W2912271293 citedByCount "22" @default.
- W2912271293 countsByYear W29122712932019 @default.
- W2912271293 countsByYear W29122712932020 @default.
- W2912271293 countsByYear W29122712932021 @default.
- W2912271293 countsByYear W29122712932022 @default.
- W2912271293 countsByYear W29122712932023 @default.
- W2912271293 crossrefType "journal-article" @default.
- W2912271293 hasAuthorship W2912271293A5013767657 @default.
- W2912271293 hasAuthorship W2912271293A5024764279 @default.
- W2912271293 hasAuthorship W2912271293A5053447705 @default.
- W2912271293 hasAuthorship W2912271293A5071773009 @default.
- W2912271293 hasAuthorship W2912271293A5072918661 @default.
- W2912271293 hasAuthorship W2912271293A5075129009 @default.
- W2912271293 hasAuthorship W2912271293A5090891106 @default.
- W2912271293 hasConcept C126322002 @default.