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- W2912272202 abstract "Abstract Summary Capture Hi-C is a powerful approach for detecting chromosomal interactions involving, at least on one end, DNA regions of interest, such as gene promoters. We present Chicdiff, an R package for robust detection of differential interactions in Capture Hi-C data. ChiScdiff enhances a state-of-the-art differential testing approach for count data with bespoke normalisation and multiple testing procedures that account for specific statistical properties of Capture Hi-C. We validate Chicdiff on published Promoter Capture Hi-C data in human Monocytes and CD4+ T cells, identifying multitudes of cell type-specific interactions, and confirming the overall positive association between promoter interactions and gene expression. Chicdiff is implemented as an R package that is publicly available at https://github.com/RegulatoryGenomicsGroup/chicdiff ." @default.
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- W2912272202 date "2019-01-22" @default.
- W2912272202 modified "2023-09-26" @default.
- W2912272202 title "Chicdiff: a computational pipeline for detecting differential chromosomal interactions in Capture Hi-C data" @default.
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- W2912272202 doi "https://doi.org/10.1101/526269" @default.
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