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- W2912272418 abstract "The past decade has seen large-scale efforts to survey the genomic landscape of most major tumour types using comprehensive whole genome, exome and transcriptome sequencing approaches. These studies have identified many of the key driver genes and pathways of tumourigenesis and progression. However, a number of knowledge gaps remain. Many rare and technically challenging tumour subtypes are yet to be characterised, non-coding and large-scale variants remain understudied, and the clinical implications of most mutations, especially with regard to treatment sensitivity, resistance and prognosis remain unknown. Initial surveys considered only a single temporal and spatial snapshot of each tumour whereas cancers are heterogenous and evolving in response to immune, treatment, and other environmental pressures. A large number of biological models (cell lines, mouse models, and xenografts) have also been developed to study cancer biology. Genomic studies are needed to establish whether these models faithfully represent the inter- and intra-tumoural molecular heterogeneity of their parent tumours. These challenges will be reviewed and recent studies will be presented that explore the next frontiers of cancer genome sequencing." @default.
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- W2912272418 date "2019-02-01" @default.
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- W2912272418 title "Surveying the genomic landscape of tumours and tumour models – the next frontier" @default.
- W2912272418 doi "https://doi.org/10.1016/j.pathol.2018.12.006" @default.
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