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- W2912274803 abstract "Gout is a common form of arthritis characterized by severe and sudden pain for a long duration, swelling, tenderness, lingering discomfort, andacute redness in the joint situated at the big toe due to the accumulation of monosodium urate (MSU) crystals. Though, at present these drugs havelimited pharmacodynamics benefits with the emergence of adverse effects. Therefore, the modern trend has perceived a shift towards the regularuse of natural products and tailored-approach, which have revolutionized the prescription pattern from traditional combinations to unexploredclasses of drugs. Natural product classes such as chalcones have received adequate attention for treating these severe ailments with a better marginof safety. Chalcone or 1,3-diphenyl-2-propene-1-one or benzylideneacetophenone are the natural scaffold comprising of two aromatic ringsconnected together by a three-carbon α, β unsaturated carbonyl link. The chalcone scaffold bearing synthetic (polyhydroxylated chalcones, 3,5,2,4-tetrahydroxychalcone, trans-chalcone) and natural (sappanchalcone, okanin, hesperidin methylchalcone, quercetin chalcone, 4-hydroxyderricin,isobavachalcone, xanthoangelol F, xanthoangelol, and xanthoangeleol B) compounds have been found to exhibit tremendous anti-gout activity bycompletely suppressing the active disease proliferating enzyme, xanthine oxidase (XO) as well as by suppressing the activation of nuclear factorkappa-light-chain-enhancer of activated B cells (NF-κβ), along with preventing the formation and influx of pro-inflammatory factors. The overviewglance of this scientific review will provide information to the scientists working in the pharmaceutical as well as allied science fields in fabricating,screening, and exploring the abundant hidden chemical classes based on the provided structural, chemical, and miscellaneous aspects." @default.
- W2912274803 created "2019-02-21" @default.
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- W2912274803 date "2019-01-01" @default.
- W2912274803 modified "2023-09-26" @default.
- W2912274803 title "RECENT THERAPEUTIC PROGRESS OF CHALCONE SCAFFOLD BEARING COMPOUNDS AS PROSPECTIVE ANTI-GOUT CANDIDATES" @default.
- W2912274803 doi "https://doi.org/10.22159/jcr.2019v6i1.31760" @default.
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