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- W2912277193 abstract "New cyclam derivatives (HOCH2 CH2 CH2 )2 (PhCH2 )2 Cyclam and (HOCH2 CH2 CH2 )2 ( 4-CF3 PhCH2 )2 Cyclam, as well as their CuII and FeIII complexes, were synthesized and characterized and their stability in cellular media was assessed. The cytotoxic effect of all compounds was examined on human cervical cancer (HeLa) cells, revealing strong anticancer activity. After 24 h, only complexes with the (HOCH2 CH2 CH2 )2 ( 4-CF3 PhCH2 )2 Cyclam ligand are cytotoxic, whereas after incubation for 72 h all compounds show significant antiproliferative effects. Notably, compounds containing 4-CF3 PhCH2 pendant arms on the cyclam ring revealed the most activity, with cytotoxicity values up to 12 times higher than those of cisplatin. All metal complexes seem to induce cell death through the formation of reactive oxygen species." @default.
- W2912277193 created "2019-02-21" @default.
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- W2912277193 date "2019-02-20" @default.
- W2912277193 modified "2023-10-18" @default.
- W2912277193 title "New Cyclams and Their Copper(II) and Iron(III) Complexes: Synthesis and Potential Application as Anticancer Agents" @default.
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- W2912277193 doi "https://doi.org/10.1002/cmdc.201800702" @default.
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