FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912277643> ?p ?o ?g. }

• W2912277643 endingPage "2043" @default.
• W2912277643 startingPage "2035" @default.
• W2912277643 abstract "Locally produced osteoclastogenic factor RANKL plays a critical role in the development of bone resorption in periradicular periodontitis. However, because RANKL is also required for healthy bone remodeling, it is plausible that a costimulatory molecule that upregulates RANKL production in inflammatory periradicular periodontitis may be involved in the pathogenic bone loss processes. We hypothesized that macrophage migration inhibitory factor (MIF) would play a role in upregulating the RANKL-mediated osteoclastogenesis in the periradicular lesion. In response to pulp exposure, the bone loss and level of MIF mRNA increased in the periradicular periodontitis, which peaked at 14 d, in conjunction with the upregulated expressions of mRNAs for RANKL, proinflammatory cytokines (TNF-α, IL-6, and IL-1β), chemokines (MCP-1 and SDF-1), and MIF's cognate receptors CXCR4 and CD74. Furthermore, expressions of those mRNAs were found significantly higher in wild-type mice compared with that of MIF-/- mice. In contrast, bacterial LPS elicited the production of MIF from ligament fibroblasts in vitro, which, in turn, enhanced their productions of RANKL and TNF-α. rMIF significantly upregulated the number of TRAP+ osteoclasts in vitro. Finally, periapical bone loss induced in wild-type mice were significantly diminished in MIF-/- mice. Altogether, the current study demonstrated that MIF appeared to function as a key costimulatory molecule to upregulate RANKL-mediated osteoclastogenesis, leading to the pathogenically augmented bone resorption in periradicular lesions. These data also suggest that the approach to neutralize MIF activity may lead to the development of a therapeutic regimen for the prevention of pathogenic bone loss in periradicular periodontitis." @default.
• W2912277643 created "2019-02-21" @default.
• W2912277643 creator A5002445778 @default.
• W2912277643 creator A5010777819 @default.
• W2912277643 creator A5011670094 @default.
• W2912277643 creator A5021545944 @default.
• W2912277643 creator A5027775199 @default.
• W2912277643 creator A5028818604 @default.
• W2912277643 creator A5032769285 @default.
• W2912277643 creator A5057605690 @default.
• W2912277643 creator A5062346969 @default.
• W2912277643 creator A5076740896 @default.
• W2912277643 creator A5086500577 @default.
• W2912277643 creator A5090554854 @default.
• W2912277643 date "2019-02-08" @default.
• W2912277643 modified "2023-10-17" @default.
• W2912277643 title "Elevated Expression of Macrophage Migration Inhibitory Factor Promotes Inflammatory Bone Resorption Induced in a Mouse Model of Periradicular Periodontitis" @default.
• W2912277643 cites W1524800873 @default.
• W2912277643 cites W1964935717 @default.
• W2912277643 cites W1965693658 @default.
• W2912277643 cites W1967062775 @default.
• W2912277643 cites W1968634783 @default.
• W2912277643 cites W1968743685 @default.
• W2912277643 cites W1976690809 @default.
• W2912277643 cites W1984727594 @default.
• W2912277643 cites W1999996381 @default.
• W2912277643 cites W2000272648 @default.
• W2912277643 cites W2012911819 @default.
• W2912277643 cites W2014481277 @default.
• W2912277643 cites W2016624612 @default.
• W2912277643 cites W2018568744 @default.
• W2912277643 cites W2019554093 @default.
• W2912277643 cites W2022211106 @default.
• W2912277643 cites W2025934097 @default.
• W2912277643 cites W2029174607 @default.
• W2912277643 cites W2032221281 @default.
• W2912277643 cites W2034124091 @default.
• W2912277643 cites W2038773592 @default.
• W2912277643 cites W2046055623 @default.
• W2912277643 cites W2046351848 @default.
• W2912277643 cites W2053870714 @default.
• W2912277643 cites W2066521125 @default.
• W2912277643 cites W2072829937 @default.
• W2912277643 cites W2074298033 @default.
• W2912277643 cites W2081601759 @default.
• W2912277643 cites W2084622111 @default.
• W2912277643 cites W2094860694 @default.
• W2912277643 cites W2100432317 @default.
• W2912277643 cites W2101232688 @default.
• W2912277643 cites W2124418728 @default.
• W2912277643 cites W2129685099 @default.
• W2912277643 cites W2131357215 @default.
• W2912277643 cites W2137486655 @default.
• W2912277643 cites W2139982581 @default.
• W2912277643 cites W2143518473 @default.
• W2912277643 cites W2152058417 @default.
• W2912277643 cites W2159695722 @default.
• W2912277643 cites W2310474609 @default.
• W2912277643 cites W2338269537 @default.
• W2912277643 cites W2370489452 @default.
• W2912277643 cites W2416306437 @default.
• W2912277643 cites W2461879822 @default.
• W2912277643 cites W2566236348 @default.
• W2912277643 cites W2595969625 @default.
• W2912277643 cites W2741312636 @default.
• W2912277643 cites W2743393351 @default.
• W2912277643 cites W2789292961 @default.
• W2912277643 cites W2810554428 @default.
• W2912277643 cites W2883419316 @default.
• W2912277643 cites W4239251959 @default.
• W2912277643 cites W2477598484 @default.
• W2912277643 doi "https://doi.org/10.4049/jimmunol.1801161" @default.
• W2912277643 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6424624" @default.
• W2912277643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30737274" @default.
• W2912277643 hasPublicationYear "2019" @default.
• W2912277643 type Work @default.
• W2912277643 sameAs 2912277643 @default.
• W2912277643 citedByCount "16" @default.
• W2912277643 countsByYear W29122776432019 @default.
• W2912277643 countsByYear W29122776432020 @default.
• W2912277643 countsByYear W29122776432021 @default.
• W2912277643 countsByYear W29122776432022 @default.
• W2912277643 countsByYear W29122776432023 @default.
• W2912277643 crossrefType "journal-article" @default.
• W2912277643 hasAuthorship W2912277643A5002445778 @default.
• W2912277643 hasAuthorship W2912277643A5010777819 @default.
• W2912277643 hasAuthorship W2912277643A5011670094 @default.
• W2912277643 hasAuthorship W2912277643A5021545944 @default.
• W2912277643 hasAuthorship W2912277643A5027775199 @default.
• W2912277643 hasAuthorship W2912277643A5028818604 @default.
• W2912277643 hasAuthorship W2912277643A5032769285 @default.
• W2912277643 hasAuthorship W2912277643A5057605690 @default.
• W2912277643 hasAuthorship W2912277643A5062346969 @default.
• W2912277643 hasAuthorship W2912277643A5076740896 @default.
• W2912277643 hasAuthorship W2912277643A5086500577 @default.
• W2912277643 hasAuthorship W2912277643A5090554854 @default.
• W2912277643 hasBestOaLocation W29122776431 @default.
• W2912277643 hasConcept C104177226 @default.

• next