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- W2912278096 abstract "Purpose: Background: Puumala hantavirus (PUUV) can cause hemorrhagic fever with renal syndrome (HFRS), an acute infection characterized by hemorrhages and kidney insufficiency. The Volga Federal District, including the Republic of Tatarstan (RT), is the most active zoonotic region where HFRS accounts for 83.3% of all zoonotic registered cases. Although PUUV is identified as the main infectious agent, little is known about the genetic variability of PUUV in the RT. Methods & Materials: Total RNA was extracted from 49 HFRS blood samples diagnosed in RT during 2015 and 2016 outbreak. RNA was used for RT-PCR analysis of the PUUV S-segment RNA. PCR products were sequenced using ABI Prism® 3730XL DNA Analyzer (ABI, USA) and analyzed using LaserGene software packet (DNASTAR, USA). Results: Phylogenetic tree analysis revealed high similarity (99.4%) between PUUV S-segment RNA isolated during 2015–2016 period. Also, PUUV RNA from 11 cases collected during 2015 outbreak clustered together with the Finish lineage with 93.0–100.0% identity. The remaining 14 PUUV RNA S-segment sequences closely resembled that of Russian lineage with 91.0–96.0% identity. Interestingly, 23 out of total 24 samples collected during the 2016 outbreak clustered with Finish lineage (93.6–99.4% identity) and only one sample clustered with Russian lineage (92.0–93.6% identity). The proportion of FIN lineage strains found in HFRS patients far exceeds the share of this lineage strains detected in populations of their native host (bank voles) in RT. Therefore, PUUV strains of the FIN lineage might be more virulent for human than the RUS lineage strains. Conclusion: This data suggest the co-circulation of two PUUV lineages FIN and RUS in the patients diagnosed with HFRS in Tatarstan. The Russian Government Program of Competitive Growth of Kazan Federal University supported this study. Also, Albert Rizvanov was supported by state assignment 20.5175.2017/6.7 of the Ministry of Education and Science of the Russian Federation." @default.
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- W2912278096 date "2019-02-01" @default.
- W2912278096 modified "2023-09-26" @default.
- W2912278096 title "Hantavirus Puumala genetic variation in the patients with HFRS in Tatarstan, Russia" @default.
- W2912278096 doi "https://doi.org/10.1016/j.ijid.2018.11.043" @default.
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