FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912281023> ?p ?o ?g. }

• W2912281023 abstract "How to improve the bioavailability of the Sanguis Draconis (SD) is an important problem in the potential clinical applications. The aim of this study was to develop a drug delivery system to achieve high bioavailability of SD, a drug with poor water solubility. It will promote the research about new formulations of the SD and the other insoluble drugs. In this study, a highly biocompatible hydrophilic polymer, polyvinylpyrrolidone (PVP), was selected as a carrier, mixed with different proportions of SD to produce SD-PVP microfibers by solution electrospinning. By orthogonal experiments, the optimal spinning conditions of the preparation of SD-PVP fibers were investigated. The morphology of different proportions of SD-PVP microfibers was observed by scanning electron microscopy, and the phase characteristics were characterized by Fourier transform infrared spectrometry, X-ray diffraction, and differential scanning calorimetry. The hydrophilic properties of SD-PVP fiber membranes with different SD content were analyzed by the water contact angle assay. In vitro dissolution experiments were carried out to observe the dissolution of drugs in SD-PVP fiber membranes. The results showed that the diameter of SD-PVP fibers increased with the enlargement of SD content. A eutectic mixture was formed after blending PVP and SD, and the hydrogen bonds were formed between the SD and PVP with no chemical reaction occurred. The dispersion of SD in the fiber decreased with the increase of SD content. The higher the content of SD in the fiber, the more hydrophobic the fiber membrane. In vitro dissolution studies revealed that the dissolution content of SD from SD-PVP microfibers was significantly higher than that of the pure or original drug SD. However, as the SD content increased from 15% to 30%, the dissolution of the drug in the SD-PVP fibers decreased. The SD-PVP fiber prepared in this study showed much higher solubility than the original drug in vitro, which has great significance for the development of new dosage forms for the clinical application of SD, and it has a useful reference for the study of similar bioavailability of poorly soluble drugs." @default.
• W2912281023 created "2019-02-21" @default.
• W2912281023 creator A5032939600 @default.
• W2912281023 creator A5049503796 @default.
• W2912281023 creator A5065867043 @default.
• W2912281023 creator A5074166500 @default.
• W2912281023 date "2019-02-09" @default.
• W2912281023 modified "2023-09-24" @default.
• W2912281023 title "Orthogonal experimental preparation of Sanguis Draconis- Polyvinylpyrrolidone microfibers by electrospinning" @default.
• W2912281023 cites W1904177755 @default.
• W2912281023 cites W1980826279 @default.
• W2912281023 cites W1989263187 @default.
• W2912281023 cites W1995980768 @default.
• W2912281023 cites W2006611597 @default.
• W2912281023 cites W2034293981 @default.
• W2912281023 cites W2046629819 @default.
• W2912281023 cites W2048939744 @default.
• W2912281023 cites W2062458432 @default.
• W2912281023 cites W2065025122 @default.
• W2912281023 cites W2078673930 @default.
• W2912281023 cites W2078860984 @default.
• W2912281023 cites W2085387111 @default.
• W2912281023 cites W2122425165 @default.
• W2912281023 cites W2126868721 @default.
• W2912281023 cites W2143543459 @default.
• W2912281023 cites W2170445914 @default.
• W2912281023 cites W2258772729 @default.
• W2912281023 cites W2471959398 @default.
• W2912281023 cites W2517200902 @default.
• W2912281023 cites W2534841478 @default.
• W2912281023 cites W2549949101 @default.
• W2912281023 cites W2561714848 @default.
• W2912281023 cites W2571458813 @default.
• W2912281023 cites W2592934094 @default.
• W2912281023 cites W2615990008 @default.
• W2912281023 cites W2759075282 @default.
• W2912281023 cites W2774633711 @default.
• W2912281023 cites W2777429651 @default.
• W2912281023 cites W2790457655 @default.
• W2912281023 cites W2901081518 @default.
• W2912281023 cites W2905930064 @default.
• W2912281023 doi "https://doi.org/10.1080/09205063.2019.1570432" @default.
• W2912281023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30686124" @default.
• W2912281023 hasPublicationYear "2019" @default.
• W2912281023 type Work @default.
• W2912281023 sameAs 2912281023 @default.
• W2912281023 citedByCount "1" @default.
• W2912281023 countsByYear W29122810232020 @default.
• W2912281023 crossrefType "journal-article" @default.
• W2912281023 hasAuthorship W2912281023A5032939600 @default.
• W2912281023 hasAuthorship W2912281023A5049503796 @default.
• W2912281023 hasAuthorship W2912281023A5065867043 @default.
• W2912281023 hasAuthorship W2912281023A5074166500 @default.
• W2912281023 hasConcept C121332964 @default.
• W2912281023 hasConcept C127413603 @default.
• W2912281023 hasConcept C12820456 @default.
• W2912281023 hasConcept C13965031 @default.
• W2912281023 hasConcept C144796933 @default.
• W2912281023 hasConcept C155574463 @default.
• W2912281023 hasConcept C159985019 @default.
• W2912281023 hasConcept C160892712 @default.
• W2912281023 hasConcept C178790620 @default.
• W2912281023 hasConcept C185592680 @default.
• W2912281023 hasConcept C188027245 @default.
• W2912281023 hasConcept C192562407 @default.
• W2912281023 hasConcept C2778551929 @default.
• W2912281023 hasConcept C2780077769 @default.
• W2912281023 hasConcept C39519442 @default.
• W2912281023 hasConcept C41625074 @default.
• W2912281023 hasConcept C42360764 @default.
• W2912281023 hasConcept C43617362 @default.
• W2912281023 hasConcept C519885992 @default.
• W2912281023 hasConcept C521977710 @default.
• W2912281023 hasConcept C55493867 @default.
• W2912281023 hasConcept C88380143 @default.
• W2912281023 hasConcept C97355855 @default.
• W2912281023 hasConceptScore W2912281023C121332964 @default.
• W2912281023 hasConceptScore W2912281023C127413603 @default.
• W2912281023 hasConceptScore W2912281023C12820456 @default.
• W2912281023 hasConceptScore W2912281023C13965031 @default.
• W2912281023 hasConceptScore W2912281023C144796933 @default.
• W2912281023 hasConceptScore W2912281023C155574463 @default.
• W2912281023 hasConceptScore W2912281023C159985019 @default.
• W2912281023 hasConceptScore W2912281023C160892712 @default.
• W2912281023 hasConceptScore W2912281023C178790620 @default.
• W2912281023 hasConceptScore W2912281023C185592680 @default.
• W2912281023 hasConceptScore W2912281023C188027245 @default.
• W2912281023 hasConceptScore W2912281023C192562407 @default.
• W2912281023 hasConceptScore W2912281023C2778551929 @default.
• W2912281023 hasConceptScore W2912281023C2780077769 @default.
• W2912281023 hasConceptScore W2912281023C39519442 @default.
• W2912281023 hasConceptScore W2912281023C41625074 @default.
• W2912281023 hasConceptScore W2912281023C42360764 @default.
• W2912281023 hasConceptScore W2912281023C43617362 @default.
• W2912281023 hasConceptScore W2912281023C519885992 @default.
• W2912281023 hasConceptScore W2912281023C521977710 @default.
• W2912281023 hasConceptScore W2912281023C55493867 @default.
• W2912281023 hasConceptScore W2912281023C88380143 @default.
• W2912281023 hasConceptScore W2912281023C97355855 @default.
• W2912281023 hasFunder F4320321001 @default.

• next