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• W2912282728 endingPage "1184" @default.
• W2912282728 startingPage "1175" @default.
• W2912282728 abstract "BackgroundMicrowave ablation (MWA) is a recognised treatment option for liver metastases. The size of the tumour is a well-established factor that influences the success of MWA. However, the effect of “heat sink” on the success of MWA for hepatic metastases is unclear. The aim of this study was to determine whether heat sink effect is a factor that contributes to ablation site recurrence (ASR).MethodsA prospectively maintained database of patients who underwent percutaneous MWA for treatment of colorectal liver metastases was analysed. Imaging and demographic characteristics were compared between metastases that recurred following ablation and those that did not. Proximity to a large hepatic vein was defined as <10 mm.Results126 ablations in 87 patients met the inclusion criteria and were studied over a median follow-up period of 28 (12–75) months. ASR was detected in 43 ablations (34%) and was associated with clinical risk score (CRS) ≥2 (OR 2.2 95% CI 1.3–3.3, p = 0.029), metastasis size (OR 0.953 95% CI (0.929–0.978), p < 0.001) and proximity to a large hepatic vein (OR 7.5 95%CI 2.4–22.8, p < 0.001). Proximity to a large hepatic vein was not associated with reduced overall survival (OS) but was associated with liver-specific recurrence (HR 4.7 95%CI 1.7–12.5, p = 0.004).ConclusionsIn addition to tumour size proximity to large hepatic venous structures is an independent predictor of ASR and liver-specific recurrence following MWA. However, this was not associated with overall survival." @default.
• W2912282728 created "2019-02-21" @default.
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• W2912282728 date "2019-09-01" @default.
• W2912282728 modified "2023-09-29" @default.
• W2912282728 title "Factors predicting ablation site recurrence following percutaneous microwave ablation of colorectal hepatic metastases" @default.
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• W2912282728 doi "https://doi.org/10.1016/j.hpb.2019.01.007" @default.
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