FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912283074> ?p ?o ?g. }

• W2912283074 endingPage "169" @default.
• W2912283074 startingPage "161" @default.
• W2912283074 abstract "Synthesis, characterization and spectroscopic investigation of maslinic acid labeled with fluorescent 7-amino-4-methylcoumarin is reported. It was found that the coumarin-maslinic derivative (MaCo) forms an excellent fluorescence resonance energy transfer (FRET) pair with the tryptophan (Trp) residue of human serum albumin (HSA). This feature allowed for monitoring HSA conformational alterations by measuring the distance between donor (Trp) and acceptor (MaCo) through Förster energy transfer mechanism. Displacement experiments confirmed that MaCo binds to subdomain IIA of HSA with independence of temperature. It was observed that, in the temperature range 35-45 °C, the fluorescence emission maximum of HSA-MaCo complex decreased, whereas in the range 45 °C-65 °C, an increment was detected. The concomitant change in the polarity of environment surrounding Trp was confirmed by red edge excitation shift experiments. Thermal denaturation of HSA was followed by time-resolved fluorescence spectroscopy. Average lifetime of Trp residue decreased with temperature due to the increment of solvent collisions and changes in the solvent exposure of Trp. To discriminate the importance of each effect, lifetime of N-Acetyl-L-tryptophanamide (NATA) at different temperatures was measured. Circular dichroism (CD) studies confirmed the loss of secondary structure of HSA with increasing temperature and showed a different trend in the conformational transformation below and above 45 °C, in agreement with steady-state and time-resolved fluorescence experiments." @default.
• W2912283074 created "2019-02-21" @default.
• W2912283074 creator A5011431723 @default.
• W2912283074 creator A5042864944 @default.
• W2912283074 creator A5053834756 @default.
• W2912283074 creator A5058436812 @default.
• W2912283074 creator A5073622294 @default.
• W2912283074 creator A5091587831 @default.
• W2912283074 date "2019-05-01" @default.
• W2912283074 modified "2023-10-17" @default.
• W2912283074 title "Maslinic acid conjugate with 7-amino-4-methylcoumarin as probe to monitor the temperature dependent conformational changes of human serum albumin by FRET" @default.
• W2912283074 cites W1504792186 @default.
• W2912283074 cites W1964935500 @default.
• W2912283074 cites W1964966079 @default.
• W2912283074 cites W1968659809 @default.
• W2912283074 cites W1980496999 @default.
• W2912283074 cites W1980550756 @default.
• W2912283074 cites W1981730902 @default.
• W2912283074 cites W1984292188 @default.
• W2912283074 cites W1985317603 @default.
• W2912283074 cites W1989371402 @default.
• W2912283074 cites W1990379353 @default.
• W2912283074 cites W1994233811 @default.
• W2912283074 cites W1995379884 @default.
• W2912283074 cites W1995556873 @default.
• W2912283074 cites W1995752389 @default.
• W2912283074 cites W1995913752 @default.
• W2912283074 cites W2004429254 @default.
• W2912283074 cites W2005904822 @default.
• W2912283074 cites W2016861604 @default.
• W2912283074 cites W2019323415 @default.
• W2912283074 cites W2027447962 @default.
• W2912283074 cites W2037488725 @default.
• W2912283074 cites W2046129838 @default.
• W2912283074 cites W2049538529 @default.
• W2912283074 cites W2057488835 @default.
• W2912283074 cites W2063680343 @default.
• W2912283074 cites W2065956733 @default.
• W2912283074 cites W2067438336 @default.
• W2912283074 cites W2067661781 @default.
• W2912283074 cites W2074055923 @default.
• W2912283074 cites W2084099308 @default.
• W2912283074 cites W2084653590 @default.
• W2912283074 cites W2085093588 @default.
• W2912283074 cites W2091281949 @default.
• W2912283074 cites W2095283711 @default.
• W2912283074 cites W2100786719 @default.
• W2912283074 cites W2104571730 @default.
• W2912283074 cites W2124186983 @default.
• W2912283074 cites W2132670708 @default.
• W2912283074 cites W214559798 @default.
• W2912283074 cites W2165456161 @default.
• W2912283074 cites W2315359473 @default.
• W2912283074 cites W2316083346 @default.
• W2912283074 cites W2318033572 @default.
• W2912283074 cites W2326164465 @default.
• W2912283074 cites W2408840056 @default.
• W2912283074 cites W2468191746 @default.
• W2912283074 cites W2603757109 @default.
• W2912283074 cites W261648421 @default.
• W2912283074 cites W2725135651 @default.
• W2912283074 cites W2766622275 @default.
• W2912283074 cites W2782703437 @default.
• W2912283074 cites W2791785968 @default.
• W2912283074 cites W2807599612 @default.
• W2912283074 cites W335769971 @default.
• W2912283074 doi "https://doi.org/10.1016/j.saa.2019.02.014" @default.
• W2912283074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30776717" @default.
• W2912283074 hasPublicationYear "2019" @default.
• W2912283074 type Work @default.
• W2912283074 sameAs 2912283074 @default.
• W2912283074 citedByCount "6" @default.
• W2912283074 countsByYear W29122830742019 @default.
• W2912283074 countsByYear W29122830742020 @default.
• W2912283074 countsByYear W29122830742021 @default.
• W2912283074 countsByYear W29122830742023 @default.
• W2912283074 crossrefType "journal-article" @default.
• W2912283074 hasAuthorship W2912283074A5011431723 @default.
• W2912283074 hasAuthorship W2912283074A5042864944 @default.
• W2912283074 hasAuthorship W2912283074A5053834756 @default.
• W2912283074 hasAuthorship W2912283074A5058436812 @default.
• W2912283074 hasAuthorship W2912283074A5073622294 @default.
• W2912283074 hasAuthorship W2912283074A5091587831 @default.
• W2912283074 hasConcept C121332964 @default.
• W2912283074 hasConcept C133571119 @default.
• W2912283074 hasConcept C185592680 @default.
• W2912283074 hasConcept C2776706248 @default.
• W2912283074 hasConcept C2777339483 @default.
• W2912283074 hasConcept C2778597219 @default.
• W2912283074 hasConcept C515207424 @default.
• W2912283074 hasConcept C55493867 @default.
• W2912283074 hasConcept C62520636 @default.
• W2912283074 hasConcept C71240020 @default.
• W2912283074 hasConcept C91881484 @default.
• W2912283074 hasConcept C96305047 @default.
• W2912283074 hasConceptScore W2912283074C121332964 @default.
• W2912283074 hasConceptScore W2912283074C133571119 @default.
• W2912283074 hasConceptScore W2912283074C185592680 @default.

• next