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- W2912283092 endingPage "1579" @default.
- W2912283092 startingPage "1569" @default.
- W2912283092 abstract "Emerging nanotechnologies for radiotherapy are attracting increasing interest from researchers in recent years. To improve the radiotherapeutic performance, developing nanoparticles that can efficiently generate toxic reactive oxygen species (ROS) under X-ray irradiation are highly desirable. Here, we investigate the potential of copper oxide nanoparticles (CuO NPs) as nanoradiosensitizers. Increased cancer cell inhibition is observed in colony formation assay and real-time cell analysis after the combined treatment with CuO NPs and X-ray irradiation, whereas the CuO NPs alone do not have any negative influence on cell viability, indicating the radiosensitization effect of CuO NPs. Importantly, the significantly increased ROS level in cells contributes to the enhanced damage to cancer cells under the combined treatment. Besides, the cell cycle is regulated to the X-ray-sensitive phase (G2/M phase) by CuO NPs, which may also account for the inhibited proliferation of cancer cells. Furthermore, results from Western blot analysis and colony formation assay reveal that the increased cell death may be mainly attributed to the excessive autophagy induced by both CuO NPs and X-ray irradiation. Moreover, in vivo experiments verify the radiosensitization of CuO NPs and their favorable biosafety. The current study suggests that CuO NPs can be utilized as nanoradiosensitizers for increasing the efficiency of cancer radiotherapy." @default.
- W2912283092 created "2019-02-21" @default.
- W2912283092 creator A5003654656 @default.
- W2912283092 creator A5015992192 @default.
- W2912283092 creator A5026713289 @default.
- W2912283092 creator A5029497819 @default.
- W2912283092 creator A5039900839 @default.
- W2912283092 creator A5055694167 @default.
- W2912283092 creator A5061691216 @default.
- W2912283092 creator A5076981458 @default.
- W2912283092 creator A5085802282 @default.
- W2912283092 date "2019-02-05" @default.
- W2912283092 modified "2023-09-30" @default.
- W2912283092 title "Copper Oxide Nanoparticles Induce Enhanced Radiosensitizing Effect via Destructive Autophagy" @default.
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- W2912283092 doi "https://doi.org/10.1021/acsbiomaterials.8b01181" @default.