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- W2912285260 abstract "Abstract Prediabetes is a serious threat of human health, and is the ideal stage for interventions against type 2 diabetes mellitus (T2DM). Oroxylum indicum has been used for centuries as a food supplement or traditional medicine in Asia for the prevention and treatment of several diseases, of which flavonoids are the major bioactive components. The combination of O. indicum extracts or flavonoids (baicalein) with acarbose, or individual flavonoids (oroxin A, baicalein) significantly reduced the relative risk of T2DM in prediabetic mice. Multiple targets and multiple pathways are involved in the prevention of diabetes by O. indicum extracts, including inhibition (oroxin A, baicalein) or synergistic inhibition (baicalein) with acarbose against α-glucosidase, improvement of insulin sensitivity (baicalein, oroxin A, chrysin), and alleviation of oxidative stress (baicalein). Therefore, food supplemented by O. indicum extracts might be beneficial for T2DM prevention or could increase the efficacy of acarbose in T2DM prevention, meanwhile lowering the side effects of acarbose." @default.
- W2912285260 created "2019-02-21" @default.
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- W2912285260 date "2019-01-01" @default.
- W2912285260 modified "2023-10-16" @default.
- W2912285260 title "Intervention of Prediabetes by Flavonoids From Oroxylum indicum" @default.
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- W2912285260 doi "https://doi.org/10.1016/b978-0-12-813822-9.00036-9" @default.
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