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- W291228602 abstract "In the past ten years nanotechonology has not only evolved to play a prominent role in our economy but also increased the concern over potential adverse effects caused by nanomaterials to human health and the environment. Nanotoxicity is to understand the nature and origin of the toxicity imposed by nanomaterials. Studies from our laboratory have shown that nanoparticle induces oxidative stress, perturbs calcium homeostasis, alter gene expression, and produces pro-inflammatory responses. We also identified a trend of toxicity: TiO2 ZnO > CuO > NiO > Fe2O3 > Mn2O3 > TiO2. The degree of adsorption on the surface of nanoparticles showed an increasing trend with atomic number, with the exception of Cr2O3. The degree of dissolution of transition metal oxides increases with atomic number. In summary, the factors that contribute to cytotoxicity of transition metal oxides were a combination of point of zero charge, number of available binding sites on the surface of nanoparticles, and metal dissolution. This study advances our understanding in mechanisms of nanotoxicity, which may lead to safer design of nanomaterials." @default.
- W291228602 created "2016-06-24" @default.
- W291228602 creator A5012267243 @default.
- W291228602 date "2012-01-01" @default.
- W291228602 modified "2023-09-27" @default.
- W291228602 title "Physiochemical characteristics contributing to the cytotoxicity of transition metal oxides" @default.
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