FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912287467> ?p ?o ?g. }

• W2912287467 endingPage "1090" @default.
• W2912287467 startingPage "1083" @default.
• W2912287467 abstract "Abstract We review here the evolution in the field of embryo aneuploidy testing over the last 20 years, from the analysis of a subset of chromosomes by fluorescence in situ hybridisation to the transition toward a more comprehensive analysis of all 24 chromosomes. This current comprehensive aneuploidy testing most commonly employs next-generation sequencing (NGS). We present our experience in over 130 000 embryo biopsies using this technology. The incidence of aneuploidy was lower in trophectoderm biopsies compared to cleavage-stage biopsies. We also confirmed by NGS that embryo aneuploidy rates increased with increasing maternal age, mostly attributable to an increase in complex aneuploid embryos. In contrast, the number of MII oocytes retrieved or the use of oocyte vitrification did not affect aneuploidy rates. Similarly, neither maternal age, oocyte number, nor oocyte vitrification affected the incidence of mosaicism. Analysis of clinical outcomes, indications, and potential benefits of embryo aneuploidy testing revealed advanced maternal age as the most favored group, with some evidence of improved delivery rate per transfer as well as decreased miscarriage rates and time to pregnancy. Other indications are: recurrent miscarriage, repetitive implantation failure, severe male factor, previous trisomic pregnancy, and good prognosis patients mainly undergoing single embryo transfer, with the latter indication used to reduce the occurrence of multiple pregnancies without compromising cycle outcome. In conclusion, NGS has become the most appropriate technology for aneuploidy testing in trophectoderm biopsies, with accurate results, high throughput, and cost efficiency. This technology can be also applied to the analysis of the embryonic cell free DNA released to the culture media at blastocyst stage. This is a promising approach towards a non-invasive preimplantation genetic testing of aneuploidy." @default.
• W2912287467 created "2019-02-21" @default.
• W2912287467 creator A5012487516 @default.
• W2912287467 creator A5063738136 @default.
• W2912287467 creator A5063880940 @default.
• W2912287467 creator A5075471436 @default.
• W2912287467 creator A5076650169 @default.
• W2912287467 creator A5079772317 @default.
• W2912287467 creator A5090345459 @default.
• W2912287467 date "2019-02-04" @default.
• W2912287467 modified "2023-10-14" @default.
• W2912287467 title "Clinical application of embryo aneuploidy testing by next-generation sequencing" @default.
• W2912287467 cites W1420884595 @default.
• W2912287467 cites W1867611649 @default.
• W2912287467 cites W1964370064 @default.
• W2912287467 cites W1980829763 @default.
• W2912287467 cites W1983529946 @default.
• W2912287467 cites W2001855994 @default.
• W2912287467 cites W2008807856 @default.
• W2912287467 cites W2016472355 @default.
• W2912287467 cites W2032600894 @default.
• W2912287467 cites W2047138255 @default.
• W2912287467 cites W2058789830 @default.
• W2912287467 cites W2062608141 @default.
• W2912287467 cites W2071534761 @default.
• W2912287467 cites W2079592358 @default.
• W2912287467 cites W2097531046 @default.
• W2912287467 cites W2104424466 @default.
• W2912287467 cites W2110099324 @default.
• W2912287467 cites W2112774354 @default.
• W2912287467 cites W2128546588 @default.
• W2912287467 cites W2129143822 @default.
• W2912287467 cites W2130012357 @default.
• W2912287467 cites W2131300747 @default.
• W2912287467 cites W2142268853 @default.
• W2912287467 cites W2155997573 @default.
• W2912287467 cites W2165474932 @default.
• W2912287467 cites W2171428075 @default.
• W2912287467 cites W2177179199 @default.
• W2912287467 cites W2232399916 @default.
• W2912287467 cites W2280635626 @default.
• W2912287467 cites W2409022067 @default.
• W2912287467 cites W2510544585 @default.
• W2912287467 cites W2524720610 @default.
• W2912287467 cites W2552000096 @default.
• W2912287467 cites W2582792555 @default.
• W2912287467 cites W2603671750 @default.
• W2912287467 cites W2606037759 @default.
• W2912287467 cites W2607487557 @default.
• W2912287467 cites W2750712999 @default.
• W2912287467 cites W2786887716 @default.
• W2912287467 cites W2795277171 @default.
• W2912287467 cites W2810219433 @default.
• W2912287467 doi "https://doi.org/10.1093/biolre/ioz019" @default.
• W2912287467 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30721942" @default.
• W2912287467 hasPublicationYear "2019" @default.
• W2912287467 type Work @default.
• W2912287467 sameAs 2912287467 @default.
• W2912287467 citedByCount "62" @default.
• W2912287467 countsByYear W29122874672019 @default.
• W2912287467 countsByYear W29122874672020 @default.
• W2912287467 countsByYear W29122874672021 @default.
• W2912287467 countsByYear W29122874672022 @default.
• W2912287467 countsByYear W29122874672023 @default.
• W2912287467 crossrefType "journal-article" @default.
• W2912287467 hasAuthorship W2912287467A5012487516 @default.
• W2912287467 hasAuthorship W2912287467A5063738136 @default.
• W2912287467 hasAuthorship W2912287467A5063880940 @default.
• W2912287467 hasAuthorship W2912287467A5075471436 @default.
• W2912287467 hasAuthorship W2912287467A5076650169 @default.
• W2912287467 hasAuthorship W2912287467A5079772317 @default.
• W2912287467 hasAuthorship W2912287467A5090345459 @default.
• W2912287467 hasConcept C104317684 @default.
• W2912287467 hasConcept C160099875 @default.
• W2912287467 hasConcept C16685009 @default.
• W2912287467 hasConcept C172680121 @default.
• W2912287467 hasConcept C196843134 @default.
• W2912287467 hasConcept C2776352029 @default.
• W2912287467 hasConcept C2776690073 @default.
• W2912287467 hasConcept C2779234561 @default.
• W2912287467 hasConcept C2779245376 @default.
• W2912287467 hasConcept C2779672484 @default.
• W2912287467 hasConcept C2780673598 @default.
• W2912287467 hasConcept C30481170 @default.
• W2912287467 hasConcept C54355233 @default.
• W2912287467 hasConcept C71924100 @default.
• W2912287467 hasConcept C86803240 @default.
• W2912287467 hasConceptScore W2912287467C104317684 @default.
• W2912287467 hasConceptScore W2912287467C160099875 @default.
• W2912287467 hasConceptScore W2912287467C16685009 @default.
• W2912287467 hasConceptScore W2912287467C172680121 @default.
• W2912287467 hasConceptScore W2912287467C196843134 @default.
• W2912287467 hasConceptScore W2912287467C2776352029 @default.
• W2912287467 hasConceptScore W2912287467C2776690073 @default.
• W2912287467 hasConceptScore W2912287467C2779234561 @default.
• W2912287467 hasConceptScore W2912287467C2779245376 @default.
• W2912287467 hasConceptScore W2912287467C2779672484 @default.
• W2912287467 hasConceptScore W2912287467C2780673598 @default.

• next