FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912287925> ?p ?o ?g. }

• W2912287925 abstract "Abstract Malaria is an acute disease that is caused by the protozoan Plasmodium parasites. Drug resistance is the major problem that is hindering the control of this disease. In order to overcome drug resistance to commonly used antimalarials, nanocarriers which are biocompatible, non-toxic, and are able to deliver drugs to the target site were designed. Polyaspartamide-drug conjugates containing antimalarials that inhibit dihydrofolate reductase were prepared and characterized by nuclear magnetic resonance spectroscopy (NMR), Fourier transform spectroscopy (FTIR), X-ray diffraction (XRD), Thermogravimetric analysis (TGA), Scanning electron microscope (SEM), Energy-dispersive X-ray analysis (EDX), particle size analysis, as well as in vitro antiplasmodial analysis and drug release studies at physiological pH values. NMR and FTIR results confirmed the successful incorporation of the drugs onto the conjugates. SEM images of the conjugates showed predominant spherical and cluster of globular morphologies. In vitro release mechanisms of the drugs from the conjugates were slow and sustained. Conjugates containing 4-aminosalicylic acid and pyrimethamine were found to be the most active against the asexual stage of the parasite with an IC50 value of 332.37 ± 6.46 nM. Conjugate containing 4-aminoquinoline derivative, pyrimethamine and primaquine exhibited moderate antimalarial activity with an IC50 value of 4.71 ± 0.70 nM." @default.
• W2912287925 created "2019-02-21" @default.
• W2912287925 creator A5001326989 @default.
• W2912287925 creator A5026755323 @default.
• W2912287925 creator A5037553997 @default.
• W2912287925 creator A5052010660 @default.
• W2912287925 creator A5081549969 @default.
• W2912287925 date "2019-04-01" @default.
• W2912287925 modified "2023-09-27" @default.
• W2912287925 title "Synthesis, characterization and in vitro analysis of polymer-based conjugates containing dihydrofolate reductase inhibitors" @default.
• W2912287925 cites W1973978403 @default.
• W2912287925 cites W1981576205 @default.
• W2912287925 cites W1986231174 @default.
• W2912287925 cites W1993373375 @default.
• W2912287925 cites W2001496295 @default.
• W2912287925 cites W2009547537 @default.
• W2912287925 cites W2010551919 @default.
• W2912287925 cites W2012881517 @default.
• W2912287925 cites W2016543522 @default.
• W2912287925 cites W2022794529 @default.
• W2912287925 cites W2033509628 @default.
• W2912287925 cites W2050926653 @default.
• W2912287925 cites W2052489889 @default.
• W2912287925 cites W2066818791 @default.
• W2912287925 cites W2071215562 @default.
• W2912287925 cites W2071867492 @default.
• W2912287925 cites W2083202259 @default.
• W2912287925 cites W2086494154 @default.
• W2912287925 cites W2095279535 @default.
• W2912287925 cites W2104931530 @default.
• W2912287925 cites W2117588046 @default.
• W2912287925 cites W2162203634 @default.
• W2912287925 cites W2168428623 @default.
• W2912287925 cites W2340309034 @default.
• W2912287925 cites W2407398900 @default.
• W2912287925 cites W2524102571 @default.
• W2912287925 cites W2525555153 @default.
• W2912287925 cites W2563046507 @default.
• W2912287925 cites W2952201742 @default.
• W2912287925 doi "https://doi.org/10.1016/j.jddst.2019.01.038" @default.
• W2912287925 hasPublicationYear "2019" @default.
• W2912287925 type Work @default.
• W2912287925 sameAs 2912287925 @default.
• W2912287925 citedByCount "10" @default.
• W2912287925 countsByYear W29122879252019 @default.
• W2912287925 countsByYear W29122879252020 @default.
• W2912287925 countsByYear W29122879252021 @default.
• W2912287925 crossrefType "journal-article" @default.
• W2912287925 hasAuthorship W2912287925A5001326989 @default.
• W2912287925 hasAuthorship W2912287925A5026755323 @default.
• W2912287925 hasAuthorship W2912287925A5037553997 @default.
• W2912287925 hasAuthorship W2912287925A5052010660 @default.
• W2912287925 hasAuthorship W2912287925A5081549969 @default.
• W2912287925 hasConcept C134306372 @default.
• W2912287925 hasConcept C13965031 @default.
• W2912287925 hasConcept C178790620 @default.
• W2912287925 hasConcept C181199279 @default.
• W2912287925 hasConcept C185592680 @default.
• W2912287925 hasConcept C197336794 @default.
• W2912287925 hasConcept C202751555 @default.
• W2912287925 hasConcept C203014093 @default.
• W2912287925 hasConcept C21951064 @default.
• W2912287925 hasConcept C2777035104 @default.
• W2912287925 hasConcept C2777752497 @default.
• W2912287925 hasConcept C2778048844 @default.
• W2912287925 hasConcept C2778371730 @default.
• W2912287925 hasConcept C2781320022 @default.
• W2912287925 hasConcept C33923547 @default.
• W2912287925 hasConcept C55493867 @default.
• W2912287925 hasConcept C60100273 @default.
• W2912287925 hasConcept C86803240 @default.
• W2912287925 hasConceptScore W2912287925C134306372 @default.
• W2912287925 hasConceptScore W2912287925C13965031 @default.
• W2912287925 hasConceptScore W2912287925C178790620 @default.
• W2912287925 hasConceptScore W2912287925C181199279 @default.
• W2912287925 hasConceptScore W2912287925C185592680 @default.
• W2912287925 hasConceptScore W2912287925C197336794 @default.
• W2912287925 hasConceptScore W2912287925C202751555 @default.
• W2912287925 hasConceptScore W2912287925C203014093 @default.
• W2912287925 hasConceptScore W2912287925C21951064 @default.
• W2912287925 hasConceptScore W2912287925C2777035104 @default.
• W2912287925 hasConceptScore W2912287925C2777752497 @default.
• W2912287925 hasConceptScore W2912287925C2778048844 @default.
• W2912287925 hasConceptScore W2912287925C2778371730 @default.
• W2912287925 hasConceptScore W2912287925C2781320022 @default.
• W2912287925 hasConceptScore W2912287925C33923547 @default.
• W2912287925 hasConceptScore W2912287925C55493867 @default.
• W2912287925 hasConceptScore W2912287925C60100273 @default.
• W2912287925 hasConceptScore W2912287925C86803240 @default.
• W2912287925 hasFunder F4320320671 @default.
• W2912287925 hasFunder F4320334626 @default.
• W2912287925 hasLocation W29122879251 @default.
• W2912287925 hasOpenAccess W2912287925 @default.
• W2912287925 hasPrimaryLocation W29122879251 @default.
• W2912287925 hasRelatedWork W1977303478 @default.
• W2912287925 hasRelatedWork W1991462349 @default.
• W2912287925 hasRelatedWork W2003000604 @default.
• W2912287925 hasRelatedWork W2008989467 @default.
• W2912287925 hasRelatedWork W2021302679 @default.
• W2912287925 hasRelatedWork W2047087145 @default.

• next