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• W2912288430 abstract "Limited data regarding methemoglobinemia in pregnancy, particularly secondary to dapsone is available up to date. We report a case of dapsone-induced methemoglobinemia in a pregnant mother with multibacillary leprosy who presented with fever, productive cough and cyanosis of 2 days duration 2 weeks after multidrug therapy was commenced. On examination, she had central cyanosis with low oxygen saturation (SpO2 = 84-88%). Arterial blood gas analysis showed PO2 of 111 mmHg and SO2 of 98 mmHg. Patient was administered 100% oxygen inhalation, but there was no improvement in cyanosis. Vitamin C (1000 mg/day) was prescribed. Dapsone was replaced by ofloxacin 200 mg twice daily. There was a gradual increase in SpO2 level. She delivered a healthy baby. In conclusion, clinicians should be aware of the side effects of dapsone and know how to promptly manage any undesirable events. Ofloxacin is a safe and feasible alternative in replacement of dapsone in pregnancy." @default.
• W2912288430 created "2019-02-21" @default.
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• W2912288430 date "2019-01-01" @default.
• W2912288430 modified "2023-09-25" @default.
• W2912288430 title "The mystery of ‘saturation gap’: a case of dapsone-induced methaemoglobinemia in a pregnant mother with leprosy" @default.
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• W2912288430 doi "https://doi.org/10.1093/omcr/omy111" @default.
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