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• W2912290452 endingPage "364" @default.
• W2912290452 startingPage "353" @default.
• W2912290452 abstract "A significant proportion of islets are lost following transplantation due to hypoxia and inflammation. We hypothesize that adipose tissue-derived mesenchymal stem cells (AD-MSCs) can rescue a sub-therapeutic number of transplanted islets by helping them establish a new blood supply and reducing inflammation. Diabetic mice received syngeneic transplantation with 75 (minimal), 150 (sub-therapeutic), or 225 (therapeutic) islets, with or without 1 × 106 mouse AD-MSCs. Fasting blood glucose (FBG) values were measured over 6 weeks with tissue samples collected for islet structure and morphology (H&E, insulin/glucagon staining). Histological and immunohistochemical analyses of islets were also performed at 2 weeks in animals transplanted with a sub-therapeutic number of islets, with and without AD-MSCs, to determine new blood vessel formation, the presence of pro-angiogenic factors facilitating revascularization, and the degree of inflammation. AD-MSCs had no beneficial effect on FBG values when co-transplanted with a minimal or therapeutic number of islets. However, AD-MSCs significantly reduced FBG values and restored glycemic control in diabetic animals transplanted with a sub-therapeutic number of islets. Islets co-transplanted with AD-MSCs preserved their native morphology and organization and exhibited less aggregation when compared to islets transplanted alone. In the sub-therapeutic group, AD-MSCs significantly increased islet revascularization and the expression of angiogenic factors including hepatocyte growth factor (HGF) and angiopoietin-1 (Ang-1) while also reducing inflammation. AD-MSCs can rescue the function of islets when transplanted in a sub-therapeutic number, for at least 6 weeks, via their ability to maintain islet architecture while concurrently facilitating islet revascularization and reducing inflammation." @default.
• W2912290452 created "2019-02-21" @default.
• W2912290452 creator A5037677450 @default.
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• W2912290452 creator A5061271062 @default.
• W2912290452 creator A5085796940 @default.
• W2912290452 date "2019-02-01" @default.
• W2912290452 modified "2023-09-28" @default.
• W2912290452 title "Adipose tissue-derived mesenchymal stem cells rescue the function of islets transplanted in sub-therapeutic numbers via their angiogenic properties" @default.
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• W2912290452 doi "https://doi.org/10.1007/s00441-019-02997-w" @default.
• W2912290452 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6615057" @default.
• W2912290452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30707291" @default.
• W2912290452 hasPublicationYear "2019" @default.
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