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• W2912290813 abstract "The PSD-95/Dlg-A/ZO-1 (PDZ) domain is highly expanded, diversified, and well distributed across metazoa where it assembles diverse signaling components by virtue of interactions with other proteins in a sequence-specific manner. In contrast, in the microbial world they are reported to be involved in protein quality control during stress response. The distribution, functions, and origins of PDZ domain-containing proteins in the prokaryotic organisms remain largely unexplored. We analyzed 7,852 PDZ domain-containing proteins in 1,474 microbial genomes in this context. PDZ domain-containing proteins from planctomycetes, myxobacteria, and other eubacteria occupying terrestrial and aquatic niches are found to be in multiple copies within their genomes. Over 93% of the 7,852 PDZ domain-containing proteins were classified into 12 families including six novel families based on additional structural and functional domains present in these proteins. The higher PDZ domain encoding capacity of the investigated organisms was observed to be associated with adaptation to the ecological niche where multicellular life might have originated and flourished. Predicted subcellular localization of PDZ domain-containing proteins and their genomic context argue in favor of crucial roles in translation and membrane remodeling during stress response. Based on rigorous sequence, structure, and phylogenetic analyses, we propose that the highly diverse PDZ domain of the uncharacterized Fe-S oxidoreductase superfamily, exclusively found in gladobacteria and several anaerobes and acetogens, might represent the most ancient form among all the existing PDZ domains." @default.
• W2912290813 created "2019-02-21" @default.
• W2912290813 creator A5015422165 @default.
• W2912290813 creator A5036749704 @default.
• W2912290813 creator A5060206301 @default.
• W2912290813 date "2019-01-29" @default.
• W2912290813 modified "2023-10-14" @default.
• W2912290813 title "PDZ Domains Across the Microbial World: Molecular Link to the Proteases, Stress Response, and Protein Synthesis" @default.
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• W2912290813 doi "https://doi.org/10.1093/gbe/evz023" @default.
• W2912290813 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6411480" @default.
• W2912290813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30698789" @default.
• W2912290813 hasPublicationYear "2019" @default.
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