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- W2912291474 abstract "Cap-binding complex (CBC) associates cotranscriptionally with the cap structure at the 5′ end of nascent mRNA to protect it from exonucleolytic degradation. Here, we show that CBC promotes the targeting of an mRNA export adaptor, Yra1 (forming transcription export [TREX] complex with THO and Sub2), to the active genes and enhances mRNA export in Saccharomyces cerevisiae. Likewise, recruitment of Npl3 (an hnRNP involved in mRNA export via formation of export-competent ribonuclear protein complex [RNP]) to the active genes is facilitated by CBC. Thus, CBC enhances targeting of the export factors and promotes mRNA export. Such function of CBC is not mediated via THO and Sub2 of TREX, cleavage and polyadenylation factors, or Sus1 (that regulates mRNA export via transcription export 2 [TREX-2]). However, CBC promotes splicing of SUS1 mRNA and, consequently, Sus1 protein level and mRNA export via TREX-2. Collectively, our results support the hypothesis that CBC promotes recruitment of Yra1 and Npl3 to the active genes, independently of THO, Sub2, or cleavage and polyadenylation factors, and enhances mRNA export via TREX and RNP, respectively, in addition to its role in facilitating SUS1 mRNA splicing to increase mRNA export through TREX-2, revealing distinct stimulatory functions of CBC in mRNA export." @default.
- W2912291474 created "2019-02-21" @default.
- W2912291474 creator A5006042739 @default.
- W2912291474 creator A5022594647 @default.
- W2912291474 creator A5041855606 @default.
- W2912291474 creator A5049229823 @default.
- W2912291474 creator A5080308532 @default.
- W2912291474 creator A5084946819 @default.
- W2912291474 creator A5089839709 @default.
- W2912291474 date "2019-04-01" @default.
- W2912291474 modified "2023-10-14" @default.
- W2912291474 title "Distinct Functions of the Cap-Binding Complex in Stimulation of Nuclear mRNA Export" @default.
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