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• W2912295684 abstract "In this study, we constructed a simian-human immunodeficiency virus carrying an R5 Kenyan HIV-1 clade A env (SHIV-A). To bypass host immunity, SHIV-A was rapidly passaged in naive macaques or animals depleted of both CD8 + and B cells. Next-generation sequencing identified different mutations that resulted from optimization of viral replicative fitness either in the absence of adaptive immunity or due to pressure from adaptive immune responses." @default.
• W2912295684 created "2019-02-21" @default.
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• W2912295684 date "2019-05-01" @default.
• W2912295684 modified "2023-09-27" @default.
• W2912295684 title "Adaptation of an R5 Simian-Human Immunodeficiency Virus Encoding an HIV Clade A Envelope with or without Ablation of Adaptive Host Immunity: Differential Selection of Viral Mutants" @default.
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• W2912295684 doi "https://doi.org/10.1128/jvi.02267-18" @default.
• W2912295684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6475780" @default.
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• W2912295684 hasPublicationYear "2019" @default.
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