Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912297089> ?p ?o ?g. }
- W2912297089 abstract "Reduced heart rate variability (HRV) and increased heart rate (HR) are associated with cardiovascular (CV) mortality. In the Liraglutide Effect and Action in Diabetes outcome trial, it was demonstrated a lower rate of CV events in type 2 diabetes (T2D) patients treated with liraglutide compared to placebo. We aimed to investigate the effects of liraglutide compared with glimepiride treatment in T2D patients on the CV risk parameters HR and HRV.This was a post hoc study whereas sixty-two T2D individuals (45 males) were randomized to once daily 1.8 mg liraglutide or once daily 4 mg glimepiride, both in combination with 1 g metformin. HR and measurement of sympathetic activity, that is standard deviation (SD) of beat-to-beat (NN) intervals (SDNN), was assessed by 24-hour Holter monitoring system. Parasympathetic activity was analysed by root mean square of successive differences (RMSSD) in NN intervals and high-frequency (HF), low-frequency (LF) and very low-frequency power.Baseline clinical characteristics for liraglutide (n = 33) and glimepiride (n = 29) groups were well matched. There was a persistent increase in diurnal HR followed by a significantly increased HR at daytime 5.4 beats per minute, P = 0.011 in the liraglutide-treated group. There was no treatment change between groups in SDNN and RMSSD, or in HF and LF frequency power analysis.Liraglutide treatment increased diurnal variation in hourly mean HR followed by an increase in mean daytime HR, independently of changes in sympathetic or parasympathetic activity." @default.
- W2912297089 created "2019-02-21" @default.
- W2912297089 creator A5014420723 @default.
- W2912297089 creator A5025259327 @default.
- W2912297089 creator A5034972791 @default.
- W2912297089 creator A5059784345 @default.
- W2912297089 creator A5073354239 @default.
- W2912297089 creator A5090697793 @default.
- W2912297089 date "2019-02-06" @default.
- W2912297089 modified "2023-10-11" @default.
- W2912297089 title "Heart rate variability in type 2 diabetic subjects randomized to liraglutide or glimepiride treatment, both in combination with metformin: A randomized, open, parallel‐group study" @default.
- W2912297089 cites W1483014275 @default.
- W2912297089 cites W1979288606 @default.
- W2912297089 cites W2000976083 @default.
- W2912297089 cites W2010000105 @default.
- W2912297089 cites W2018666069 @default.
- W2912297089 cites W2039240461 @default.
- W2912297089 cites W2042025489 @default.
- W2912297089 cites W2105391780 @default.
- W2912297089 cites W2118765312 @default.
- W2912297089 cites W2129730863 @default.
- W2912297089 cites W2134843796 @default.
- W2912297089 cites W2138969187 @default.
- W2912297089 cites W2141917858 @default.
- W2912297089 cites W2145270758 @default.
- W2912297089 cites W2147973767 @default.
- W2912297089 cites W2170271198 @default.
- W2912297089 cites W2171459914 @default.
- W2912297089 cites W2176491627 @default.
- W2912297089 cites W2264072095 @default.
- W2912297089 cites W2282578582 @default.
- W2912297089 cites W2425644022 @default.
- W2912297089 cites W2519510391 @default.
- W2912297089 cites W2535492942 @default.
- W2912297089 cites W2536045672 @default.
- W2912297089 cites W2754041380 @default.
- W2912297089 cites W2767216468 @default.
- W2912297089 cites W2770135881 @default.
- W2912297089 cites W2790243797 @default.
- W2912297089 cites W2887185538 @default.
- W2912297089 cites W2888680621 @default.
- W2912297089 cites W4236391198 @default.
- W2912297089 cites W4252086597 @default.
- W2912297089 cites W4252795044 @default.
- W2912297089 doi "https://doi.org/10.1002/edm2.58" @default.
- W2912297089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6458482" @default.
- W2912297089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31008366" @default.
- W2912297089 hasPublicationYear "2019" @default.
- W2912297089 type Work @default.
- W2912297089 sameAs 2912297089 @default.
- W2912297089 citedByCount "8" @default.
- W2912297089 countsByYear W29122970892019 @default.
- W2912297089 countsByYear W29122970892020 @default.
- W2912297089 countsByYear W29122970892021 @default.
- W2912297089 countsByYear W29122970892022 @default.
- W2912297089 countsByYear W29122970892023 @default.
- W2912297089 crossrefType "journal-article" @default.
- W2912297089 hasAuthorship W2912297089A5014420723 @default.
- W2912297089 hasAuthorship W2912297089A5025259327 @default.
- W2912297089 hasAuthorship W2912297089A5034972791 @default.
- W2912297089 hasAuthorship W2912297089A5059784345 @default.
- W2912297089 hasAuthorship W2912297089A5073354239 @default.
- W2912297089 hasAuthorship W2912297089A5090697793 @default.
- W2912297089 hasBestOaLocation W29122970891 @default.
- W2912297089 hasConcept C126322002 @default.
- W2912297089 hasConcept C134018914 @default.
- W2912297089 hasConcept C142724271 @default.
- W2912297089 hasConcept C164705383 @default.
- W2912297089 hasConcept C204787440 @default.
- W2912297089 hasConcept C27081682 @default.
- W2912297089 hasConcept C2776307423 @default.
- W2912297089 hasConcept C2777180221 @default.
- W2912297089 hasConcept C2777953023 @default.
- W2912297089 hasConcept C2780323712 @default.
- W2912297089 hasConcept C2781308992 @default.
- W2912297089 hasConcept C555293320 @default.
- W2912297089 hasConcept C67761136 @default.
- W2912297089 hasConcept C71635504 @default.
- W2912297089 hasConcept C71924100 @default.
- W2912297089 hasConcept C84393581 @default.
- W2912297089 hasConceptScore W2912297089C126322002 @default.
- W2912297089 hasConceptScore W2912297089C134018914 @default.
- W2912297089 hasConceptScore W2912297089C142724271 @default.
- W2912297089 hasConceptScore W2912297089C164705383 @default.
- W2912297089 hasConceptScore W2912297089C204787440 @default.
- W2912297089 hasConceptScore W2912297089C27081682 @default.
- W2912297089 hasConceptScore W2912297089C2776307423 @default.
- W2912297089 hasConceptScore W2912297089C2777180221 @default.
- W2912297089 hasConceptScore W2912297089C2777953023 @default.
- W2912297089 hasConceptScore W2912297089C2780323712 @default.
- W2912297089 hasConceptScore W2912297089C2781308992 @default.
- W2912297089 hasConceptScore W2912297089C555293320 @default.
- W2912297089 hasConceptScore W2912297089C67761136 @default.
- W2912297089 hasConceptScore W2912297089C71635504 @default.
- W2912297089 hasConceptScore W2912297089C71924100 @default.
- W2912297089 hasConceptScore W2912297089C84393581 @default.
- W2912297089 hasFunder F4320322436 @default.
- W2912297089 hasIssue "2" @default.
- W2912297089 hasLocation W29122970891 @default.
- W2912297089 hasLocation W29122970892 @default.