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- W2912297206 endingPage "271" @default.
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- W2912297206 abstract "The endoplasmic reticulum (ER) is the primary organelle responsible for the synthesis, modification, folding and secretion of proteins, especially in specialized secretory cells. It also contributes to the maintenance of cellular functions, such as Ca2+ storage, lipogenesis, gluconeogenesis, and organelle biogenesis. Cellular stress conditions, such as glucose deprivation, hypoxia and disturbance of Ca2+ homeostasis, may increase the risk of protein misfolding and perturb proteostasis. This activates ER stress and triggers the unfolded protein response (UPR), leading to either the restoration of homeostasis or cell death. ER stress and UPR have been shown to play crucial roles in the pathogenesis, progression and treatment response of various cancers. In gastric cancer (GC), one of the most aggressive cancer types, critical functions of ER stress signaling have also started to emerge. Herein, we summarize the current knowledge linking ER stress and UPR to GC; we also discuss the possible nodes of therapeutic intervention and propose directions of future research." @default.
- W2912297206 created "2019-02-21" @default.
- W2912297206 creator A5001276137 @default.
- W2912297206 creator A5066705400 @default.
- W2912297206 creator A5073531557 @default.
- W2912297206 creator A5079594267 @default.
- W2912297206 date "2019-05-01" @default.
- W2912297206 modified "2023-10-13" @default.
- W2912297206 title "Endoplasmic reticulum proteostasis control and gastric cancer" @default.
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