FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912298207> ?p ?o ?g. }

• W2912298207 endingPage "280" @default.
• W2912298207 startingPage "274" @default.
• W2912298207 abstract "Depression is associated with dysregulation of methyl group metabolism such as low S-adenosylmethionine (SAM). We previously reported that Flinders Sensitive Line (FSL) rats, an animal model of depression, had lower concentrations of liver SAM than the control rats, Flinders Resistant Line (FRL) rats. The present study investigated if SAM supplementation may correct liver SAM and behavioral abnormalities in this model. Moreover, we compared one-carbon (C1) metabolites, neurotransmitters, and gastrointestinal (GI) transit in SAM-treated versus imipramine (IMI)-treated animals. FSL rats received vehicle, IMI, SAM, or IMI + SAM (n = 9–10 per group) once daily through oral gavage for 4 weeks; FRL rats received vehicle. Behavior was assessed using standard tests for locomotion, cognition, and depressive-like behavior. Monoamine neurotransmitters and C1 metabolites were measured using UHPLC‐ECD and UPLC‐MS/MS, respectively. Compared to FRL rats, FSLs had lower liver SAM, higher plasma serotonin, lower hippocampal dopamine and serotonin turnover, and faster GI transit. Behaviorally, FSL rats showed impaired cognitive performance as well as increased depressive-like behavior compared to FRLs. Coadministration of IMI and SAM seemed to have adverse effects on spatial memory. SAM or IMI administration did not reverse C1 metabolites, neurotransmitters, or GI transit in FSLs. Despite low liver SAM in FSL rats, orally administered SAM did not show antidepressant effects in this specific animal model of depression." @default.
• W2912298207 created "2019-02-21" @default.
• W2912298207 creator A5007280256 @default.
• W2912298207 creator A5012173155 @default.
• W2912298207 creator A5048096775 @default.
• W2912298207 creator A5053209684 @default.
• W2912298207 creator A5067551418 @default.
• W2912298207 creator A5079908433 @default.
• W2912298207 date "2019-05-01" @default.
• W2912298207 modified "2023-09-27" @default.
• W2912298207 title "Behavioral and metabolic effects of S-adenosylmethionine and imipramine in the Flinders Sensitive Line rat model of depression" @default.
• W2912298207 cites W1966427309 @default.
• W2912298207 cites W1986257859 @default.
• W2912298207 cites W1991527095 @default.
• W2912298207 cites W2000990708 @default.
• W2912298207 cites W2008741517 @default.
• W2912298207 cites W2013626321 @default.
• W2912298207 cites W2017772802 @default.
• W2912298207 cites W2029933753 @default.
• W2912298207 cites W2030680920 @default.
• W2912298207 cites W2034433299 @default.
• W2912298207 cites W2035617128 @default.
• W2912298207 cites W2035789411 @default.
• W2912298207 cites W2040103405 @default.
• W2912298207 cites W2043101749 @default.
• W2912298207 cites W2057489281 @default.
• W2912298207 cites W2075166335 @default.
• W2912298207 cites W2080049485 @default.
• W2912298207 cites W2087171263 @default.
• W2912298207 cites W2095253451 @default.
• W2912298207 cites W2096738301 @default.
• W2912298207 cites W2097013495 @default.
• W2912298207 cites W2120626403 @default.
• W2912298207 cites W2130067887 @default.
• W2912298207 cites W2155959499 @default.
• W2912298207 cites W2591085270 @default.
• W2912298207 cites W2745014256 @default.
• W2912298207 cites W2792121859 @default.
• W2912298207 cites W2889321101 @default.
• W2912298207 cites W4229642588 @default.
• W2912298207 doi "https://doi.org/10.1016/j.bbr.2019.02.011" @default.
• W2912298207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30738101" @default.
• W2912298207 hasPublicationYear "2019" @default.
• W2912298207 type Work @default.
• W2912298207 sameAs 2912298207 @default.
• W2912298207 citedByCount "9" @default.
• W2912298207 countsByYear W29122982072019 @default.
• W2912298207 countsByYear W29122982072020 @default.
• W2912298207 countsByYear W29122982072021 @default.
• W2912298207 countsByYear W29122982072022 @default.
• W2912298207 countsByYear W29122982072023 @default.
• W2912298207 crossrefType "journal-article" @default.
• W2912298207 hasAuthorship W2912298207A5007280256 @default.
• W2912298207 hasAuthorship W2912298207A5012173155 @default.
• W2912298207 hasAuthorship W2912298207A5048096775 @default.
• W2912298207 hasAuthorship W2912298207A5053209684 @default.
• W2912298207 hasAuthorship W2912298207A5067551418 @default.
• W2912298207 hasAuthorship W2912298207A5079908433 @default.
• W2912298207 hasConcept C126322002 @default.
• W2912298207 hasConcept C134018914 @default.
• W2912298207 hasConcept C142724271 @default.
• W2912298207 hasConcept C15744967 @default.
• W2912298207 hasConcept C170493617 @default.
• W2912298207 hasConcept C187714386 @default.
• W2912298207 hasConcept C204787440 @default.
• W2912298207 hasConcept C2775864247 @default.
• W2912298207 hasConcept C2776134451 @default.
• W2912298207 hasConcept C2776219046 @default.
• W2912298207 hasConcept C2778875871 @default.
• W2912298207 hasConcept C2779145073 @default.
• W2912298207 hasConcept C2779177272 @default.
• W2912298207 hasConcept C2781161787 @default.
• W2912298207 hasConcept C513476851 @default.
• W2912298207 hasConcept C529278444 @default.
• W2912298207 hasConcept C71924100 @default.
• W2912298207 hasConceptScore W2912298207C126322002 @default.
• W2912298207 hasConceptScore W2912298207C134018914 @default.
• W2912298207 hasConceptScore W2912298207C142724271 @default.
• W2912298207 hasConceptScore W2912298207C15744967 @default.
• W2912298207 hasConceptScore W2912298207C170493617 @default.
• W2912298207 hasConceptScore W2912298207C187714386 @default.
• W2912298207 hasConceptScore W2912298207C204787440 @default.
• W2912298207 hasConceptScore W2912298207C2775864247 @default.
• W2912298207 hasConceptScore W2912298207C2776134451 @default.
• W2912298207 hasConceptScore W2912298207C2776219046 @default.
• W2912298207 hasConceptScore W2912298207C2778875871 @default.
• W2912298207 hasConceptScore W2912298207C2779145073 @default.
• W2912298207 hasConceptScore W2912298207C2779177272 @default.
• W2912298207 hasConceptScore W2912298207C2781161787 @default.
• W2912298207 hasConceptScore W2912298207C513476851 @default.
• W2912298207 hasConceptScore W2912298207C529278444 @default.
• W2912298207 hasConceptScore W2912298207C71924100 @default.
• W2912298207 hasLocation W29122982071 @default.
• W2912298207 hasLocation W29122982072 @default.
• W2912298207 hasOpenAccess W2912298207 @default.
• W2912298207 hasPrimaryLocation W29122982071 @default.
• W2912298207 hasRelatedWork W1508094410 @default.
• W2912298207 hasRelatedWork W1966518441 @default.

• next