Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912299554> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2912299554 endingPage "1131" @default.
- W2912299554 startingPage "1127" @default.
- W2912299554 abstract "Recently, rare-earth elements lanthanides (Ln3+) have emerged as enzyme cofactors of methanol dehydrogenases of the XoxF type. It is now understood that XoxF enzymes can functionally replace the alternative, calcium-dependent, MxaFI-type methanol dehydrogenases, when Ln3+ are available. These rare-earth metals are not only essential for XoxF activity, but they also regulate gene expression, in a reverse fashion, activating the expression of XoxF and repressing the expression of MxaFI. This type of regulation has created multiple conundrums, including the details of the solubility, transport, sensing and selection mechanisms for Ln3+ by the bacterial cells, as well as the questions relevant to the evolution of the alternative enzymes and their potentially different redox properties. Overall, the newly discovered biological activity of Ln3+ presents a big puzzle. Ochsner et al. add several pieces to this puzzle, utilizing a model phyllosphere colonizer Methylobacterium extorquens PA1. They determine that Ln3+ sensing by this organism can take place via both XoxF-dependent and XoxF-independent mechanisms. They also identify genes for a TonB-dependent transporter and an ABC-type transporter and demonstrate that both are essential for Ln3+-dependent methanol metabolism. The puzzle still requires multiple additional pieces for completion, but great strides have been made toward the goal of solving it." @default.
- W2912299554 created "2019-02-21" @default.
- W2912299554 creator A5075869324 @default.
- W2912299554 date "2019-03-28" @default.
- W2912299554 modified "2023-10-17" @default.
- W2912299554 title "New pieces to the lanthanide puzzle" @default.
- W2912299554 cites W1957272202 @default.
- W2912299554 cites W1966289358 @default.
- W2912299554 cites W2038683125 @default.
- W2912299554 cites W2040537350 @default.
- W2912299554 cites W2048741503 @default.
- W2912299554 cites W2065606854 @default.
- W2912299554 cites W2094249190 @default.
- W2912299554 cites W2134909120 @default.
- W2912299554 cites W2149640337 @default.
- W2912299554 cites W2157979560 @default.
- W2912299554 cites W2183095896 @default.
- W2912299554 cites W2282878913 @default.
- W2912299554 cites W2330388767 @default.
- W2912299554 cites W2470324306 @default.
- W2912299554 cites W2512982221 @default.
- W2912299554 cites W2563657428 @default.
- W2912299554 cites W2726647464 @default.
- W2912299554 cites W2763085503 @default.
- W2912299554 cites W2768844486 @default.
- W2912299554 cites W2793594459 @default.
- W2912299554 cites W2793970972 @default.
- W2912299554 cites W2897349895 @default.
- W2912299554 cites W2898540180 @default.
- W2912299554 cites W2903131692 @default.
- W2912299554 cites W2909280300 @default.
- W2912299554 cites W2950199663 @default.
- W2912299554 cites W4211191980 @default.
- W2912299554 doi "https://doi.org/10.1111/mmi.14210" @default.
- W2912299554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30673122" @default.
- W2912299554 hasPublicationYear "2019" @default.
- W2912299554 type Work @default.
- W2912299554 sameAs 2912299554 @default.
- W2912299554 citedByCount "28" @default.
- W2912299554 countsByYear W29122995542019 @default.
- W2912299554 countsByYear W29122995542020 @default.
- W2912299554 countsByYear W29122995542021 @default.
- W2912299554 countsByYear W29122995542022 @default.
- W2912299554 countsByYear W29122995542023 @default.
- W2912299554 crossrefType "journal-article" @default.
- W2912299554 hasAuthorship W2912299554A5075869324 @default.
- W2912299554 hasBestOaLocation W29122995541 @default.
- W2912299554 hasConcept C104317684 @default.
- W2912299554 hasConcept C149011108 @default.
- W2912299554 hasConcept C181199279 @default.
- W2912299554 hasConcept C197957613 @default.
- W2912299554 hasConcept C2778973328 @default.
- W2912299554 hasConcept C55493867 @default.
- W2912299554 hasConcept C70721500 @default.
- W2912299554 hasConcept C86803240 @default.
- W2912299554 hasConceptScore W2912299554C104317684 @default.
- W2912299554 hasConceptScore W2912299554C149011108 @default.
- W2912299554 hasConceptScore W2912299554C181199279 @default.
- W2912299554 hasConceptScore W2912299554C197957613 @default.
- W2912299554 hasConceptScore W2912299554C2778973328 @default.
- W2912299554 hasConceptScore W2912299554C55493867 @default.
- W2912299554 hasConceptScore W2912299554C70721500 @default.
- W2912299554 hasConceptScore W2912299554C86803240 @default.
- W2912299554 hasFunder F4320306084 @default.
- W2912299554 hasIssue "5" @default.
- W2912299554 hasLocation W29122995541 @default.
- W2912299554 hasLocation W29122995542 @default.
- W2912299554 hasLocation W29122995543 @default.
- W2912299554 hasOpenAccess W2912299554 @default.
- W2912299554 hasPrimaryLocation W29122995541 @default.
- W2912299554 hasRelatedWork W1164537646 @default.
- W2912299554 hasRelatedWork W13108389 @default.
- W2912299554 hasRelatedWork W1572197712 @default.
- W2912299554 hasRelatedWork W169735115 @default.
- W2912299554 hasRelatedWork W1953994264 @default.
- W2912299554 hasRelatedWork W2080203695 @default.
- W2912299554 hasRelatedWork W2094248253 @default.
- W2912299554 hasRelatedWork W3007588004 @default.
- W2912299554 hasRelatedWork W4242974861 @default.
- W2912299554 hasRelatedWork W4285133860 @default.
- W2912299554 hasVolume "111" @default.
- W2912299554 isParatext "false" @default.
- W2912299554 isRetracted "false" @default.
- W2912299554 magId "2912299554" @default.
- W2912299554 workType "article" @default.