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- W2912300353 abstract "Purpose: Functional dyspepsia (FD) is common, impacts on quality of life and is very costly. The etiopathogenesis is uncertain. While in irritable bowel syndrome there is evidence that genetic and intra-familial factors may be involved, this has not been studied in FD. We hypothesized that if there is familial aggregation, there would be an increased frequency of FD in first-degree relatives of FD patients compared with relatives of controls (the patient's spouse). Methods: The study design was a case-control study. Cases had undergone a negative esophagogastroduodenoscopy at the Mayo Clinic for assessment of dyspeptic symptoms; 455 were randomly selected from the endoscopy database using the relevant diagnostic codes. A self report bowel disease questionnaire (BDQ) that recorded symptoms, the somatic symptom checklist, and a family information form (FIF) to collect the names and addresses of all first-degree relatives were mailed to all cases and their spouses. A BDQ was then mailed to all first-degree relatives of study subjects identified from the FIF. FD diagnosis was based on the Rome II criteria. Results: The study design was a case-control study. Cases had undergone a negative esophagogastroduodenoscopy at the Mayo Clinic for assessment of dyspeptic symptoms; 455 were randomly selected from the endoscopy database using the relevant diagnostic codes. A self report bowel disease questionnaire (BDQ) that recorded symptoms, the somatic symptom checklist, and a family information form (FIF) to collect the names and addresses of all first-degree relatives were mailed to all cases and their spouses. A BDQ was then mailed to all first-degree relatives of study subjects identified from the FIF. FD diagnosis was based on the Rome II criteria. Conclusions: This study suggests familial aggregation of FD occurs, supporting a genetic or intra-familial environment component. GRANT SUPPORT: Dr. Halder is the recipient of an ACG Clinical Research Award." @default.
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- W2912300353 date "2006-09-01" @default.
- W2912300353 modified "2023-09-23" @default.
- W2912300353 title "Familial Aggregation of Functional Dyspepsia" @default.
- W2912300353 doi "https://doi.org/10.14309/00000434-200609001-01260" @default.
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