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- W2912302330 abstract "Dysregulation of the cyclin D1-CDK4/6-RB pathways results in increased proliferation, and frequently observed in many types of cancer. Due to the importance of the CDK4/6 activity in cancer cells, CDK4/6 inhibitors have emerged as promising candidates for cancer treatment especially for hormonal receptor–positive (HR+) breast cancer patients to help to overcome the acquired or de novo hormonal treatment resistance. In particular, the combination of CD4/6 inhibitors with endocrine therapy in first-line and after hormonal failure is expected to transform the treatment of HR+ breast cancer. Currently, three selective CD4/6 inhibitors have been approved or are in the late phase of development. Here we describe the efficacy and safety from the most relevant clinical data for these novel agents." @default.
- W2912302330 created "2019-02-21" @default.
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- W2912302330 date "2018-08-10" @default.
- W2912302330 modified "2023-09-25" @default.
- W2912302330 title "The Therapeutic Effects of Specific CDK4/6-Inhibitors in Treating Hormone Receptor-Positive Advanced Breast Cancer" @default.
- W2912302330 hasPublicationYear "2018" @default.
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