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- W2912303644 abstract "Musculoskeletal disorders are a significant burden on the global economy and public health. Advanced drug delivery plays a key role in the musculoskeletal field and holds the promise of enhancing the repair of degenerated and injured musculoskeletal tissues. Ideally, drug delivery should have the ability to directly deliver therapeutic agents to the diseased/injured sites with a desirable drug level over a period of time. Here, we present a mini-review of the current state-of-the-art research associated with local drug delivery and its use for the treatment of musculoskeletal disorders. First, an overview of drug delivery strategies, with a focus on issues related to musculoskeletal pathology, potential therapeutic strategies, conventional and non-conventional drugs, and various delivery systems, is introduced. Then, we highlight recent advances in the emerging fields of musculoskeletal local drug delivery, involving therapeutic drugs (e.g., genes, small molecule therapeutics, and stem cells), novel delivery vehicles (e.g., 3D printing and tissue engineering techniques), and innovative delivery approaches (e.g., multi-drug delivery and smart stimuli-responsive delivery). The review concludes with future perspectives and associated challenges for developing local drug delivery for musculoskeletal applications. STATEMENT OF SIGNIFICANCE: Three important aspects are highlighted in this manuscript: 1) The advanced musculoskeletal drug delivery is introduced from the aspects ranging from musculoskeletal disorders, potential therapeutic solutions, and various drug delivery systems. 2) The recent advances in the emerging fields of musculoskeletal local drug delivery, involving therapeutic drugs (e.g., genes, small molecule therapeutics, and stem cells), novel delivery vehicles (e.g., 3D printing and tissue engineering technique), and innovative delivery approaches (e.g., multi-drug delivery and smart stimuli-responsive delivery), are highlighted. 3) The challenges and perspectives of future research directions in the development of musculoskeletal local drug delivery are presented." @default.
- W2912303644 created "2019-02-21" @default.
- W2912303644 creator A5005381049 @default.
- W2912303644 creator A5080788081 @default.
- W2912303644 creator A5091364911 @default.
- W2912303644 date "2019-07-01" @default.
- W2912303644 modified "2023-10-13" @default.
- W2912303644 title "Recent advances in musculoskeletal local drug delivery" @default.
- W2912303644 cites W1551080197 @default.
- W2912303644 cites W1564553363 @default.
- W2912303644 cites W1821415384 @default.
- W2912303644 cites W1850477204 @default.
- W2912303644 cites W1899098391 @default.
- W2912303644 cites W1915856409 @default.
- W2912303644 cites W1922993671 @default.
- W2912303644 cites W1963973481 @default.
- W2912303644 cites W1965904237 @default.
- W2912303644 cites W1971339046 @default.
- W2912303644 cites W1972325038 @default.
- W2912303644 cites W1972856448 @default.
- W2912303644 cites W1977525640 @default.
- W2912303644 cites W1980306509 @default.
- W2912303644 cites W1981953910 @default.
- W2912303644 cites W1984317348 @default.
- W2912303644 cites W1985006605 @default.
- W2912303644 cites W1986715280 @default.
- W2912303644 cites W1986747880 @default.
- W2912303644 cites W1988106932 @default.
- W2912303644 cites W1988644925 @default.
- W2912303644 cites W1991409289 @default.
- W2912303644 cites W1993123310 @default.
- W2912303644 cites W1993882629 @default.
- W2912303644 cites W2001380203 @default.
- W2912303644 cites W2006146856 @default.
- W2912303644 cites W2011935103 @default.
- W2912303644 cites W2012217795 @default.
- W2912303644 cites W2012251902 @default.
- W2912303644 cites W2012814486 @default.
- W2912303644 cites W2013355421 @default.
- W2912303644 cites W2016530312 @default.
- W2912303644 cites W2016935436 @default.
- W2912303644 cites W2018486096 @default.
- W2912303644 cites W2018613635 @default.
- W2912303644 cites W2018922007 @default.
- W2912303644 cites W2024659370 @default.
- W2912303644 cites W2026975571 @default.
- W2912303644 cites W2032555145 @default.
- W2912303644 cites W2033577259 @default.
- W2912303644 cites W2039873297 @default.
- W2912303644 cites W2040009239 @default.
- W2912303644 cites W2040071171 @default.
- W2912303644 cites W2043007466 @default.
- W2912303644 cites W2043575440 @default.
- W2912303644 cites W2048361405 @default.
- W2912303644 cites W2048946993 @default.
- W2912303644 cites W2049921049 @default.
- W2912303644 cites W2051959623 @default.
- W2912303644 cites W2055119128 @default.
- W2912303644 cites W2056104115 @default.
- W2912303644 cites W2065575328 @default.
- W2912303644 cites W2068126429 @default.
- W2912303644 cites W2069578225 @default.
- W2912303644 cites W2070737759 @default.
- W2912303644 cites W2070974940 @default.
- W2912303644 cites W2074727818 @default.
- W2912303644 cites W2076333986 @default.
- W2912303644 cites W2080926589 @default.
- W2912303644 cites W2082692776 @default.
- W2912303644 cites W2085502170 @default.
- W2912303644 cites W2089863521 @default.
- W2912303644 cites W2091084072 @default.
- W2912303644 cites W2092448261 @default.
- W2912303644 cites W2094562739 @default.
- W2912303644 cites W2095931643 @default.
- W2912303644 cites W2097080974 @default.
- W2912303644 cites W2102849564 @default.
- W2912303644 cites W2105265282 @default.
- W2912303644 cites W2109446452 @default.
- W2912303644 cites W2112944423 @default.
- W2912303644 cites W2113698463 @default.
- W2912303644 cites W2114773747 @default.
- W2912303644 cites W2117315764 @default.
- W2912303644 cites W2119064342 @default.
- W2912303644 cites W2120980993 @default.
- W2912303644 cites W2130166533 @default.
- W2912303644 cites W2134755472 @default.
- W2912303644 cites W2139619092 @default.
- W2912303644 cites W2143772132 @default.
- W2912303644 cites W2144843667 @default.
- W2912303644 cites W2151340599 @default.
- W2912303644 cites W2155943302 @default.
- W2912303644 cites W2166479549 @default.
- W2912303644 cites W2166849504 @default.
- W2912303644 cites W2171057955 @default.
- W2912303644 cites W2176956992 @default.
- W2912303644 cites W2183777073 @default.
- W2912303644 cites W2230774605 @default.
- W2912303644 cites W2233888390 @default.