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- W2912304807 abstract "The four B-family DNA polymerases α, δ, ϵ and ζ cooperate to accurately replicate the eukaryotic nuclear genome. Here, we report that a Saccharomyces cerevisiae strain encoding the pol2-16 mutation that lacks Pol ϵ's polymerase and exonuclease activities has increased dNTP concentrations and an increased mutation rate at the CAN1 locus compared to wild type yeast. About half of this mutagenesis disappears upon deleting the REV3 gene encoding the catalytic subunit of Pol ζ. The remaining, still strong, mutator phenotype is synergistically elevated in an msh6Δ strain and has a mutation spectrum characteristic of mistakes made by Pol δ. The results support a model wherein slow-moving replication forks caused by the lack of Pol ϵ's catalytic domains result in greater involvement of mutagenic DNA synthesis by Pol ζ as well as diminished proofreading by Pol δ during replication." @default.
- W2912304807 created "2019-02-21" @default.
- W2912304807 creator A5006041544 @default.
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- W2912304807 creator A5072131585 @default.
- W2912304807 creator A5084461634 @default.
- W2912304807 date "2019-01-30" @default.
- W2912304807 modified "2023-10-14" @default.
- W2912304807 title "The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity" @default.
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- W2912304807 cites W1848529922 @default.
- W2912304807 cites W1963876890 @default.
- W2912304807 cites W1971558110 @default.
- W2912304807 cites W1976279799 @default.
- W2912304807 cites W1979209991 @default.
- W2912304807 cites W1980042463 @default.
- W2912304807 cites W1985491895 @default.
- W2912304807 cites W1992391204 @default.
- W2912304807 cites W1993705842 @default.
- W2912304807 cites W1993724028 @default.
- W2912304807 cites W1994051286 @default.
- W2912304807 cites W1995377068 @default.
- W2912304807 cites W2001031455 @default.
- W2912304807 cites W2003922055 @default.
- W2912304807 cites W2007446614 @default.
- W2912304807 cites W2008554680 @default.
- W2912304807 cites W2014941097 @default.
- W2912304807 cites W2016357039 @default.
- W2912304807 cites W2018764160 @default.
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- W2912304807 cites W2118873017 @default.
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- W2912304807 doi "https://doi.org/10.1093/nar/gkz048" @default.
- W2912304807 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6486559" @default.
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- W2912304807 hasPublicationYear "2019" @default.
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