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- W2912304870 abstract "There is mounting evidence that seemingly diverse psychiatric disorders share genetic etiology, but the biological substrates mediating this overlap are not well characterized. Here we leverage the unique Integrative Psychiatric Research Consortium (iPSYCH) study, a nationally representative cohort ascertained through clinical psychiatric diagnoses indicated in Danish national health registers. We confirm previous reports of individual and cross-disorder single-nucleotide polymorphism heritability for major psychiatric disorders and perform a cross-disorder genome-wide association study. We identify four novel genome-wide significant loci encompassing variants predicted to regulate genes expressed in radial glia and interneurons in the developing neocortex during mid-gestation. This epoch is supported by partitioning cross-disorder single-nucleotide polymorphism heritability, which is enriched at regulatory chromatin active during fetal neurodevelopment. These findings suggest that dysregulation of genes that direct neurodevelopment by common genetic variants may result in general liability for many later psychiatric outcomes." @default.
- W2912304870 created "2019-02-21" @default.
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- W2912304870 date "2019-01-28" @default.
- W2912304870 modified "2023-10-18" @default.
- W2912304870 title "A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment" @default.
- W2912304870 cites W1221735883 @default.
- W2912304870 cites W1533942137 @default.
- W2912304870 cites W1562623676 @default.
- W2912304870 cites W1767184367 @default.
- W2912304870 cites W1855058198 @default.
- W2912304870 cites W1964895626 @default.
- W2912304870 cites W1969040276 @default.
- W2912304870 cites W1978848619 @default.
- W2912304870 cites W1981041672 @default.
- W2912304870 cites W1990174682 @default.
- W2912304870 cites W1991704577 @default.
- W2912304870 cites W1992094322 @default.
- W2912304870 cites W1992436001 @default.
- W2912304870 cites W2006216826 @default.
- W2912304870 cites W2008047653 @default.
- W2912304870 cites W2009669230 @default.
- W2912304870 cites W2012453547 @default.
- W2912304870 cites W2019465651 @default.
- W2912304870 cites W2022689242 @default.
- W2912304870 cites W2022941468 @default.
- W2912304870 cites W2033151532 @default.
- W2912304870 cites W2034008819 @default.
- W2912304870 cites W2035543772 @default.
- W2912304870 cites W2039897057 @default.
- W2912304870 cites W2043282585 @default.
- W2912304870 cites W2045227722 @default.
- W2912304870 cites W2065692954 @default.
- W2912304870 cites W2071598557 @default.
- W2912304870 cites W2076154138 @default.
- W2912304870 cites W2082704080 @default.
- W2912304870 cites W2091947960 @default.
- W2912304870 cites W2097401631 @default.
- W2912304870 cites W2098143048 @default.
- W2912304870 cites W2099085143 @default.
- W2912304870 cites W2100531973 @default.
- W2912304870 cites W2101357408 @default.
- W2912304870 cites W2102213696 @default.
- W2912304870 cites W2102420102 @default.
- W2912304870 cites W2102924526 @default.
- W2912304870 cites W2104549677 @default.
- W2912304870 cites W2105057146 @default.
- W2912304870 cites W2105370140 @default.
- W2912304870 cites W2106949460 @default.
- W2912304870 cites W2107807525 @default.
- W2912304870 cites W2108169091 @default.
- W2912304870 cites W2117177609 @default.
- W2912304870 cites W2118462346 @default.
- W2912304870 cites W2125972459 @default.
- W2912304870 cites W2129031013 @default.
- W2912304870 cites W2132145985 @default.
- W2912304870 cites W2136115410 @default.
- W2912304870 cites W2139852368 @default.
- W2912304870 cites W2144338201 @default.
- W2912304870 cites W2145748421 @default.
- W2912304870 cites W2146453000 @default.
- W2912304870 cites W2153773863 @default.
- W2912304870 cites W2153860431 @default.
- W2912304870 cites W2155496693 @default.
- W2912304870 cites W2156691676 @default.
- W2912304870 cites W2157752701 @default.
- W2912304870 cites W2166643977 @default.
- W2912304870 cites W2168505085 @default.
- W2912304870 cites W2170090311 @default.
- W2912304870 cites W2170703764 @default.
- W2912304870 cites W2195783463 @default.
- W2912304870 cites W2219110856 @default.
- W2912304870 cites W2297334215 @default.
- W2912304870 cites W2337092408 @default.
- W2912304870 cites W2406728433 @default.