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- W2912305031 abstract "Ophiobolin A is a fungal secondary metabolite that was found to have significant activity against apoptosis-resistant glioblastoma cells through the induction of a non-apoptotic cell death, offering an innovative strategy to combat this aggressive cancer. The current article aims to make the bridge between the anti-cancer effects of ophiobolin A and its unique reaction with primary amines and suggests that pyrrolylation of lysine residues on its intracellular target protein(s) and/or phosphatidylethanolamine lipid is responsible for its biological effects. The article also discusses chemical derivatization of ophiobolin A to establish first synthetically generated structure-activity relationship. Finally, the reported total synthesis efforts toward the ophiobolin class of sesterterpenes are discussed and identified as a fertile area for improvement in pursuit of these molecules as anticancer agents." @default.
- W2912305031 created "2019-02-21" @default.
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- W2912305031 date "2019-04-01" @default.
- W2912305031 modified "2023-10-16" @default.
- W2912305031 title "Chemistry and biology of ophiobolin A and its congeners" @default.
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- W2912305031 doi "https://doi.org/10.1016/j.bmcl.2019.02.007" @default.
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