FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2912305676> ?p ?o ?g. }

• W2912305676 abstract "Abstract Hepatocellular carcinoma (HCC) is the most prevalent subtype of liver cancer, and it is characterized by high rate of metastasis and recurrence. Recent studies have boosted our understanding that Gankyrin contributes to both of these pathological properties, but the mechanisms underlying its aberrant regulation are poorly understood. Recently, many long noncoding RNAs (lncRNAs) have been reported to be involved in regulating the expression of oncogenes and anti-oncogenes through various mechanisms. Here, using transcriptome microarray analysis, we identified a long intergenic noncoding RNA termed Linc-GALH that was highly expressed and concordance with Gankyrin expression in HCC. In addition, we revealed that Linc-GALH was an independent unfavorable prognostic indicator for HCC, followed functional experiments showed that Linc-GALH promoted HCC cells migration and invasion in vitro, and enhanced lung metastasis ability of HCC cells in vivo. Mechanistically, we found that Linc-GALH could regulate the expression of Gankyrin through controlling the methylation status of Gankyrin by adjusting the ubiquitination status of DNMT1 in HCC. Collectively, our results demonstrated the role and functional mechanism of Linc-GALH in HCC, and indicated that Linc-GALH may act as a prognostic biomarker and potential therapeutic target for HCC." @default.
• W2912305676 created "2019-02-21" @default.
• W2912305676 creator A5004636265 @default.
• W2912305676 creator A5024436953 @default.
• W2912305676 creator A5038212610 @default.
• W2912305676 creator A5041895823 @default.
• W2912305676 creator A5042726887 @default.
• W2912305676 creator A5048535438 @default.
• W2912305676 creator A5051044101 @default.
• W2912305676 creator A5073533203 @default.
• W2912305676 date "2019-01-28" @default.
• W2912305676 modified "2023-10-14" @default.
• W2912305676 title "The long non-coding RNA Linc-GALH promotes hepatocellular carcinoma metastasis via epigenetically regulating Gankyrin" @default.
• W2912305676 cites W1491983812 @default.
• W2912305676 cites W1966382767 @default.
• W2912305676 cites W1972317605 @default.
• W2912305676 cites W1980153364 @default.
• W2912305676 cites W1983416011 @default.
• W2912305676 cites W1991504495 @default.
• W2912305676 cites W2000564844 @default.
• W2912305676 cites W2016027959 @default.
• W2912305676 cites W2044724701 @default.
• W2912305676 cites W2084918027 @default.
• W2912305676 cites W2091161969 @default.
• W2912305676 cites W2094262537 @default.
• W2912305676 cites W2126170617 @default.
• W2912305676 cites W2141763464 @default.
• W2912305676 cites W2143510008 @default.
• W2912305676 cites W2156203169 @default.
• W2912305676 cites W2167962791 @default.
• W2912305676 cites W2523408665 @default.
• W2912305676 cites W2542690450 @default.
• W2912305676 cites W2549253282 @default.
• W2912305676 cites W2617831789 @default.
• W2912305676 cites W2763764277 @default.
• W2912305676 cites W2772898778 @default.
• W2912305676 cites W2774490145 @default.
• W2912305676 cites W2792272990 @default.
• W2912305676 cites W2795382323 @default.
• W2912305676 cites W2804525414 @default.
• W2912305676 cites W2807795508 @default.
• W2912305676 cites W2886094455 @default.
• W2912305676 cites W2888800941 @default.
• W2912305676 cites W2888806409 @default.
• W2912305676 cites W2890466051 @default.
• W2912305676 cites W2891412523 @default.
• W2912305676 cites W2917837889 @default.
• W2912305676 cites W3143765497 @default.
• W2912305676 doi "https://doi.org/10.1038/s41419-019-1348-0" @default.
• W2912305676 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6349924" @default.
• W2912305676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30692513" @default.
• W2912305676 hasPublicationYear "2019" @default.
• W2912305676 type Work @default.
• W2912305676 sameAs 2912305676 @default.
• W2912305676 citedByCount "32" @default.
• W2912305676 countsByYear W29123056762019 @default.
• W2912305676 countsByYear W29123056762020 @default.
• W2912305676 countsByYear W29123056762021 @default.
• W2912305676 countsByYear W29123056762022 @default.
• W2912305676 countsByYear W29123056762023 @default.
• W2912305676 crossrefType "journal-article" @default.
• W2912305676 hasAuthorship W2912305676A5004636265 @default.
• W2912305676 hasAuthorship W2912305676A5024436953 @default.
• W2912305676 hasAuthorship W2912305676A5038212610 @default.
• W2912305676 hasAuthorship W2912305676A5041895823 @default.
• W2912305676 hasAuthorship W2912305676A5042726887 @default.
• W2912305676 hasAuthorship W2912305676A5048535438 @default.
• W2912305676 hasAuthorship W2912305676A5051044101 @default.
• W2912305676 hasAuthorship W2912305676A5073533203 @default.
• W2912305676 hasBestOaLocation W29123056761 @default.
• W2912305676 hasConcept C104317684 @default.
• W2912305676 hasConcept C121608353 @default.
• W2912305676 hasConcept C150194340 @default.
• W2912305676 hasConcept C162317418 @default.
• W2912305676 hasConcept C190727270 @default.
• W2912305676 hasConcept C2778019345 @default.
• W2912305676 hasConcept C2779013556 @default.
• W2912305676 hasConcept C2909856833 @default.
• W2912305676 hasConcept C33288867 @default.
• W2912305676 hasConcept C502942594 @default.
• W2912305676 hasConcept C54355233 @default.
• W2912305676 hasConcept C62203573 @default.
• W2912305676 hasConcept C67705224 @default.
• W2912305676 hasConcept C86803240 @default.
• W2912305676 hasConcept C91965660 @default.
• W2912305676 hasConceptScore W2912305676C104317684 @default.
• W2912305676 hasConceptScore W2912305676C121608353 @default.
• W2912305676 hasConceptScore W2912305676C150194340 @default.
• W2912305676 hasConceptScore W2912305676C162317418 @default.
• W2912305676 hasConceptScore W2912305676C190727270 @default.
• W2912305676 hasConceptScore W2912305676C2778019345 @default.
• W2912305676 hasConceptScore W2912305676C2779013556 @default.
• W2912305676 hasConceptScore W2912305676C2909856833 @default.
• W2912305676 hasConceptScore W2912305676C33288867 @default.
• W2912305676 hasConceptScore W2912305676C502942594 @default.
• W2912305676 hasConceptScore W2912305676C54355233 @default.
• W2912305676 hasConceptScore W2912305676C62203573 @default.
• W2912305676 hasConceptScore W2912305676C67705224 @default.
• W2912305676 hasConceptScore W2912305676C86803240 @default.
• W2912305676 hasConceptScore W2912305676C91965660 @default.

• next