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• W2912305963 abstract "Purpose: Liver cirrhosis (LC) is characterized by pathological changes in homeostatic mechanisms which regulate the extracellular fluid volume. The changes of hydration status are estimate by Bioelectrical Impedance Analysis (BIA), a simple, inexpensive, non-invasive, patient-bed method. We evaluate the safety of BIA in LC. Methods: We enrolled 48 patients (62 ± 9 yr, 27 male) admitted to our department with diagnosis of LC subdivided in three groups on the basis of Child-Pugh score (A group: 14 pts; B group: 17 pts; C group: 15 pts). There were no statistically significant differences in age and gender in each group. 16 healthy volunteers and 16 non-cirrhotic pts with a clear hyperhydration status (heart failure, kidney failure, nephrotic syndrome), matched for age and sex, were considered like controls. All the subjects underwent to blood tests, BIA-101 for detecting whole-body BIA measurements (Resistance: R; Reactance: Xc) and abdominal ultrasonography. Results: Showed a significant reduction of parameters from A (R 537 ± 33, Xc 46 ± 7) to B (R 480 ± 28, Xc 38 ± 6) and C group (R 450 ± 29, Xc 35 ± 5). We observed a statistically significant reduction (P < .001) between hyperhydrated (R 445 ± 31, Xc 36 ± 8) (R 544 ± 33, Xc 47 ± 8) vs. healthy controls measurements. No significant differences between hyperhydrated controls and B or C group was found. These results correlated inversely with Child-Pugh score (P < .001), serum creatinine (P < .01), directly with albumin (P < .01), plasma sodium levels (P < .01), hematocrit (P < .01). When we classified the pts on the basis of ultrasonography presence of ascites not significant difference of bioelectrical parameters between moderate and tense ascites was found. Classifying the pts according to presence of ascites and to preserved or compromised liver function we observed a more significant reduction of these values (P < .001) in ascitic pts with compromised liver function. Analyzing the subgroup of pts with ascites and normal BIA values we found that all had a preserved liver function. Conclusion: BIA is a repeatible non operator-dependent method helpful for evaluation of hydration status in LC and correlates with clinical-functional class. Thus it is not capable of estimating the entity of ascites because it is a compartmentalized edema. However this method is useful for rapid evaluation of severity of disease and selection of pts with ascites for diuretic treatment (lower BIA values) or paracentesis (normal BIA values)." @default.
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• W2912305963 date "2007-09-01" @default.
• W2912305963 modified "2023-09-25" @default.
• W2912305963 title "Safety of Bioelectrical Impedance Analysis in Evaluation of Patients with Liver Cirrhosis and Relation with Severity of Disease" @default.
• W2912305963 doi "https://doi.org/10.14309/00000434-200709002-00352" @default.
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